Abstract
Magnesium salts bind dietary phosphorus, but their use in renal patients is limited due to their potential for causing side effects. The aim of this study was to evaluate the efficacy and safety of magnesium carbonate (MgCO(3)) as a phosphate-binder in hemodialysis patients. Forty-six stable hemodialysis patients were randomly allocated to receive either MgCO(3) (n=25) or calcium carbonate (CaCO(3)), (n=21) for 6 months. The concentration of Mg in the dialysate bath was 0.30 mmol/l in the MgCO(3) group and 0.48 mmol/l in the CaCO(3) group. Only two of 25 patients (8%) discontinued ingestion of MgCO(3) due to complications: one (4%) because of persistent diarrhea, and the other (4%) because of recurrent hypermagnesemia. In the MgCO(3) and CaCO(3) groups, respectively, time-averaged (months 1-6) serum concentrations were: phosphate (P), 5.47 vs. 5.29 mg/dl, P=ns; Ca, 9.13 vs. 9.60 mg/dl, P<0.001; Ca x P product, 50.35 vs. 50.70 (mg/dl)(2), P=ns; Mg, 2.57 vs. 2.41 mg/dl, P=ns; intact parathyroid hormone (iPTH), 285 vs. 235 pg/ml, P<0.01. At month 6, iPTH levels did not differ between groups: 251 vs. 212 pg/ml, P=ns. At month 6 the percentages of patients with serum levels of phosphate, Ca x P product and iPTH that fell within the ...Continue Reading
References
Jan 1, 1991·Annual Review of Physiology·Z S Agus, M Morad
Apr 19, 1986·Lancet·R O'DonovanV Parsons
Jan 1, 1988·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P MorinièreD Roche
Oct 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G M ShahA M Horowitz
Sep 1, 1987·Kidney International·H E MeemaA Rapoport
Jan 1, 1982·Nephron·A P GuillotF J Gennari
Apr 1, 1980·Acta Endocrinologica·V ParsonsJ L O'Riordan
Nov 1, 1993·Journal of the American Society of Nephrology : JASN·J T Daugirdas
Aug 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J T Daugirdas
Jan 1, 1996·Kidney International·J A DelmezE Slatopolsky
Nov 5, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B Bastani, D Frenchie
Nov 5, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I TzanakisN Kallivretakis
Sep 16, 1998·Nephron·H SahaA Pasternack
Jun 26, 2002·Kidney International·Glenn M ChertowUNKNOWN Treat to Goal Working Group
Oct 10, 2002·Nephron·Anita C TruttmannMario G Bianchetti
Jan 23, 2003·Molecular Aspects of Medicine·Jeanette A M Maier
Apr 17, 2004·Kidney International·Wajeh Y QunibiCharles R Nolan
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Geoffrey A BlockGlenn M Chertow
Jun 3, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hans-Gernot AsmusJürgen Bommer
Mar 23, 2006·Clinical Nephrology·I TzanakisN Kallivretakis
Jul 27, 2006·International Urology and Nephrology·Mingxin WeiDimitrios G Oreopoulos
Dec 1, 2006·Kidney International. Supplement·T Drüeke, R N Foley
Dec 1, 2006·Kidney International. Supplement·I B Salusky
Nov 1, 2007·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·David M SpiegelMichel Chonchol
Apr 22, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Wajeh QunibiUNKNOWN CARE-2 Investigators
Citations
Nov 28, 2008·International Urology and Nephrology·Krishnaswamy Sampathkumar
Dec 31, 2008·International Urology and Nephrology·Ioannis P Tzanakis, Dimitrios G Oreopoulos
Apr 30, 2013·Drugs·Fabio Malberti
Apr 9, 2010·The New England Journal of Medicine·Marcello TonelliBraden Manns
Jun 10, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Angel L M de FranciscoJutta Passlick-Deetjen
Jul 1, 2009·Nephrology·Stacey O'Shea, David W Johnson
Dec 24, 2010·Seminars in Dialysis·Richard K Kasama
May 5, 2012·Nephron. Clinical Practice·João M Frazão, Teresa Adragão
Sep 12, 2013·Nephron. Clinical Practice·Indranil DasguptaUNKNOWN NICE Hyperphosphataemia Guideline Development Group
Jan 1, 2011·Health Economics Review·Thomas PlagemannThomas Mittendorf
Oct 12, 2013·International Urology and Nephrology·Yuan-Mei HeYun-Hua Liao
Sep 17, 2015·Expert Opinion on Pharmacotherapy·Goce Spasovski
Jun 11, 2014·Expert Opinion on Pharmacotherapy·Francesco LocatelliGoce Spasovski
Dec 19, 2015·Expert Opinion on Pharmacotherapy·Pavlos Malindretos, Mario Cozzolino
Apr 8, 2014·Expert Opinion on Drug Safety·Francesco LocatelliGiuseppe Pontoriero
Mar 15, 2013·Kidney International·Tineke M De SchutterEllen Neven
May 15, 2012·Advances in Chronic Kidney Disease·David M Spiegel
May 31, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Katarzyna WyskidaAndrzej Więcek
Mar 27, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ranjani N MoorthiKatrin Uhlig
Jun 3, 2015·Clinical and Experimental Nephrology·Fateme Shamekhi Amiri
Jun 14, 2017·Seminars in Dialysis·Paraish S Misra, Sharon J Nessim
Aug 23, 2018·The Cochrane Database of Systematic Reviews·Marinella RuospoGiovanni Fm Strippoli
May 9, 2018·Journal of Cardiovascular Pharmacology·Zhihui YaoCongxia Wang
Aug 28, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Akinobu OchiMasaaki Inaba
Mar 1, 2014·American Journal of Nephrology·Mohamad AlhosainiDavid J Leehey
Mar 4, 2014·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Baigalmaa EvsanaaTabo Sikaneta
Feb 15, 2020·Expert Opinion on Pharmacotherapy·Mariana Hollanda Martins Da RochaJoel Faintuch
Feb 1, 2012·Clinical Kidney Journal·Alastair J Hutchison, Martin Wilkie
Aug 5, 2017·JPEN. Journal of Parenteral and Enteral Nutrition·Xiuqin YangXiaolei Zhang
May 23, 2019·Hemodialysis International·Vipul V ChakurkarValentine A Lobo
Feb 18, 2011·The Cochrane Database of Systematic Reviews·Sankar D NavaneethanGiovanni Fm Strippoli
Jul 12, 2020·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Rafael Pérez-GarcíaRoberto Alcázar
Aug 2, 2017·Kidney International·Juan M Diaz-TocadosJuan R Muñoz-Castañeda