Magnesium deficiency enhances hydrogen peroxide production and oxidative damage in chick embryo hepatocyte in vitro

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Ying YangYuming Guo

Abstract

Magnesium deficiency and oxidative stress have been identified as correlative factors in many diseases. The origin of free radicals correlated with oxidative damage resulting from Mg-deficiency is unclear at the cellular level. To investigate whether hydrogen peroxide (H2O2) is associated in the oxidative stress induced by Mg-deficiency, the effect of Mg2+ deficiency (0, 0.4, 0.7 mM) on the metabolism of H2O2 was investigated in cultured chick embryo hepatocytes. After being cultured in the media with various concentrations of Mg2+ for 1, 2, 4, 6 and 10 days, parameters of H2O2 production, catalase activity, lipid peroxidation, intracellular total Mg and cell viability were analyzed. Results demonstrated that long-term incubation of chick embryo hepatocyte in extracellular Mg2+-deprivative and Mg2+-deficient (0.4 mM) states significantly enhanced the production of H2O2 (approximately twofold, respectively) and lipid peroxidation in the cell cultures, while decreasing the cell viability. Additionally, the reversing action of Mg2+ re-added to 1.0 mM and the partial reversing action of dimethylthiourea suggested that (i) [Mg2+]e deficiency induced the increase of H2O2 production, (ii) [Mg2+]e deficiency decreased catalase activity...Continue Reading

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Citations

Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·David W Killilea, Bruce N Ames
Aug 14, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jie WangGraeme F Mason
Apr 12, 2014·International Journal of Endocrinology·Marcello MaggioGian Paolo Ceda
Jan 28, 2014·Metabolism: Clinical and Experimental·Mario BarbagalloLigia J Dominguez
Jun 20, 2013·BioMed Research International·Ana Lúcia Vargas ArigonyJoão Antonio Pêgas Henriques
Dec 1, 2007·Clinical Science·Federica I Wolf, Valentina Trapani
Jun 27, 2020·Biological Trace Element Research·Mohammad Mahdi BelkamehArash Azarfar
Oct 1, 2020·International Journal of Molecular Sciences·Fabiana da Silva Lima, Ricardo Ambrósio Fock
Jul 25, 2021·Journal of Industrial Microbiology & Biotechnology·Luis B Flores-CoteraOscar Ulises García-Flores

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