Magnesium deficiency induces an hyperalgesia reversed by the NMDA receptor antagonist MK801

Neuroreport
C DubrayJ Lavarenne

Abstract

The aim of this study was to determine the changes of the nociceptive thresholds in response to an acute mechanical stimulus (paw pressure) in magnesium (Mg)-deficient rats, and the involvement of the NMDA receptor in these changes. Changes in vocalization thresholds was determined after 7 days of feeding with a Mg-depleted diet. Compared with the control group, Mg-deficient rats showed a significant decrease in the vocalization thresholds (-35.8 +/- 2.5%, p < 0.001) reflecting hyperalgesia. In Mg-deprived rats, three doses (0.06, 0.12 and 0.24 mg/kg s.c.) of dizocilpine (MK801), a non-competitive NMDA receptor antagonist, significantly reversed the hyperalgesia in a dose-dependent manner for at least 48 h. No effect of MK801 was observed in the control group. These data provide evidence that Mg deficiency could constitute a new model of hyperalgesia involving NMDA receptors.

References

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Citations

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Sep 14, 2000·European Journal of Pain : EJP·D JourdanJ Alliot
Dec 4, 2003·Expert Opinion on Pharmacotherapy·Chonghao Zhao, Mark J Stillman
Jan 25, 2006·Acta Anaesthesiologica Scandinavica·S M JeongS M Han
Jan 24, 2006·Acta Oto-laryngologica·Isabelle SendowskiAnne Braillon-Cros
May 12, 2005·Journal of Vascular Surgery·Hongjiang ChenMohammed M Moursi
Mar 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zbigniew Zylicz, Robert Twycross
Jun 16, 2018·BMJ Supportive & Palliative Care·Séamus Coyle, Daniel Monnery
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