PMID: 9634675Jun 23, 1998Paper

Magnesium in cerebrospinal fluid in acute cerebral ischemia: its relation to glutamate neurotoxicity

Revista de neurologia
C Vázquez-EspierrezE Martínez-Vila

Abstract

In animal models it has been shown that there is an increase in tissue magnesium concentration during cerebral ischemia. We studied the changes in magnesium levels in the cerebrospinal fluid (CSF) during the acute phase of cerebral ischemia. We included 95 patients with first ischemic cerebral infarcts admitted to hospital within the first 24 hours and also 37 controls. CT scan was done on admission and between four and seven days later (when the volume of the infarct was determined). The neurological defect was evaluated on the Canadian scale on admission, after 48 hours, on the seventh day and after three months. The CSF magnesium concentration was determined using a colorimetric method and the glutamate by HPLC. The CSF magnesium concentrations were significantly higher in the patients than in the controls (2.6 +/- 0.6 mmol/l vs 2.2 +/- 0.6 mmol/l p = 0.0001). The magnesium concentration was higher in the larger infarcts (Pearson's coefficient = 0.2901, p = 0.0043), and in those presenting greater neurological defects after 48 hours (Spearman's coefficient = -0.4649, p < 0.0001). The magnesium concentration was not related to the presence of early signs on the initial CT scan and the Canadian scale rating on admission. The c...Continue Reading

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.