Magnesium infusion reduces perioperative pain

European Journal of Anaesthesiology
H KaraT Aydogdu

Abstract

Magnesium has antinociceptive effects in animal and human models of pain. These effects are primarily based on the regulation of calcium influx into the cell. The aim of this study was to determine whether perioperative infusion of magnesium would reduce postoperative pain and anxiety. Twenty-four patients, undergoing elective hysterectomy, received a bolus of 30 mg kg(-1) magnesium sulphate or the same volume of isotonic sodium chloride solution intravenously before the start of surgery and 0.5 g h(-1) infusion for the next 20 h. Intraoperative and postoperative analgesia were achieved with fentanyl and morphine respectively. Patients were evaluated pre- and postoperatively for anxiety. Fentanyl consumption and total morphine requirements were significantly decreased in the magnesium group compared to the control group. Postoperative anxiety scores and sedation were similar between groups. Continuous magnesium infusion, including the pre-, intra-, and postoperative periods reduces analgesic requirements. These results demonstrate that magnesium can be an adjuvant for perioperative analgesic management.

References

Aug 1, 1989·British Journal of Anaesthesia·H Kehlet
Jul 1, 1984·American Heart Journal·L T Iseri, J H French
Feb 1, 1996·Anesthesiology·M R TramerK Rifat

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Citations

Jun 15, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Perihan EkmekciArif Hikmet Suer
Feb 1, 2003·Neuropharmacology·Rashid GiniatullinAndrea Nistri
Feb 20, 2010·Revista brasileira de anestesiologia·Fabiano Timbó BarbosaRafael Martins da Cunha
Aug 16, 2013·Obstetrical & Gynecological Survey·Laleh AzariShelby E Osborne
Sep 11, 2014·Journal of Clinical Anesthesia·Hassan SoleimanpourMaryam Soleimanpour
Feb 1, 2005·European Journal of Anaesthesiology·A ApanH Basar
Sep 17, 2005·European Journal of Anaesthesiology·K SatohR Ogawa
May 25, 2007·Allergy·G D'AmatoP van Cauwenberge
Dec 26, 2015·Anesthesiology and Pain Medicine·Seyed Sajad RazaviSeyed Amir Mohajerani
Aug 2, 2013·Korean journal of anesthesiology·Sang-Hwan Do
Dec 18, 2013·Seminars in Cardiothoracic and Vascular Anesthesia·Brandi A BottigerMark Stafford-Smith
Nov 3, 2016·Journal of Anesthesia·Marija S KutlesicTatjana Mostic-Ilic
Aug 29, 2020·International Journal of Molecular Sciences·Petra HnilicováEma Kantorová
Jul 13, 2006·European Journal of Anaesthesiology·P Tauzin-FinP Maurette
Jun 22, 2012·European Journal of Anaesthesiology·Younes AissaouiMohammed Boughalem
Mar 8, 2020·Journal of Veterinary Pharmacology and Therapeutics·Denis R GomesRenata N Cassu
May 22, 2007·Anesthesia and Analgesia·Christopher LysakowskiMartin R Tramèr
Jan 13, 2021·BMJ Case Reports·Frank Arthur CirnigliaroMoira Rush
Oct 7, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Scott S Reuben, Lakshmi Yalavarthy

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