Magnesium isoglycyrrhizinate blocks fructose-induced hepatic NF-κB/NLRP3 inflammasome activation and lipid metabolism disorder.

European Journal of Pharmacology
Xiao-Juan ZhaoLing-Dong Kong

Abstract

Magnesium isoglycyrrhizinate as a hepatoprotective agent possesses immune modulation and anti-inflammation, and treats liver diseases. But its effects on immunological-inflammatory and metabolic profiles for metabolic syndrome with liver injury and underlying potential mechanisms are not fully understood. In this study, magnesium isoglycyrrhizinate alleviated liver inflammation and lipid accumulation in fructose-fed rats with metabolic syndrome. It also suppressed hepatic inflammatory signaling activation by reducing protein levels of phosphorylation of nuclear factor-kappa B p65 (p-NF-κB p65), inhibitor of nuclear factor kappa-B kinase α/β (p-IKKα/β) and inhibitor of NF-κB α (p-IκBα) as well as nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein (ASC) and Caspase-1 in rats, being consistent with its reduction of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and IL-6 levels. Furthermore, magnesium isoglycyrrhizinate modulated lipid metabolism-related genes characterized by up-regulating peroxisome proliferator-activated receptor-α (PPAR-α) and carnitine palmitoyl transferase-1 (CPT-1), and down-regulating sensor for fatty acids to control-1 (SREBP-1) and stearoyl-Co...Continue Reading

Citations

May 12, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Shuai JiangYang Yang
Oct 31, 2019·International Journal of Environmental Research and Public Health·Ren LinLihong Jia
Oct 22, 2020·The Journal of International Medical Research·Hui YanJian Li
Aug 18, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nan BoYuan Yuan
Nov 7, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ju-Tao YuXiao-Ming Meng
Dec 24, 2020·Acta Biochimica Et Biophysica Sinica·Chenguang LiDongyun Ouyang

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