PMID: 2115080Jul 1, 1990Paper

Magnesium metabolism in preterm infants: effects of calcium, magnesium, and phosphorus, and of postnatal and gestational age

The Journal of Pediatrics
M M GilesR Hume

Abstract

This study tests the hypothesis that increasing the calcium and phosphorus content of formulas for very low birth weight (VLBW) infants to the level required to decrease the incidence of rickets has a negative impact on magnesium balance. Using formulas variously supplemented with these minerals, we measured absorption and retention in two groups of preterm infants: (1) VLBW infants, less than 1500 gm and at less than 32 weeks of gestational age, with 3-day mineral balances begun at days 10, 20, 30, and 40; and (2) low birth weight infants appropriately grown and at 32 to 34 weeks of gestational age, with a single 3-day balance begun at day 10. Magnesium did not affect calcium balance in VLBW or low birth weight infants but promoted phosphorus retention in VLBW infants from day 20 onward. Absorption and retention of magnesium increased with postnatal age in VLBW infants, but this effect was obvious only when calcium or phosphorus intakes were low or when magnesium intake was high. Calcium and phosphorus supplementation further reduced magnesium absorption and retention in VLBW infants to the extent that they were in negative balance throughout the study; however, magnesium supplementation improved absorption and retention in VL...Continue Reading

Citations

Aug 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G AricetaA Vallo
Sep 15, 1997·The Science of the Total Environment·C GámezM C López
Apr 14, 2000·Journal of the American College of Nutrition·J G Dórea
Apr 1, 1997·Critical Reviews in Food Science and Nutrition·L H Foster, S Sumar
Aug 16, 2012·The Kaohsiung Journal of Medical Sciences·Hung-Yi ChenYi-Ling Chen
Mar 23, 2007·Neonatology·Vasileios I GiaprosStyliani K Andronikou
Oct 1, 1995·Journal of the American College of Nutrition·P S Venkataraman, R T Tsang
Aug 1, 1996·Annals of Medicine·M C BackströmR Mäki

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