PMID: 3383985Jan 1, 1988Paper

Magnesium pyridoxal 5-phosphate glutamate reduces hyperlipidaemia in patients with chronic renal insufficiency

European Journal of Clinical Pharmacology
R KirstenU Speck

Abstract

Chronic renal insufficiency is often accompanied by hyperlipidaemia and subsequent coronary heart disease. Two groups of 15 patients with serum creatinine greater than 2 mg/100 ml and serum cholesterol less than 250 mg/100 ml were given 3 x 50 mg magnesium pyridoxal 5-phosphate glutamate (MPPG) or placebo for 12 weeks in a double-blind, randomised study. Total cholesterol in the MPPG group (282.4 mg.100 ml-1) was lower than in the placebo group (354.3 mg.100 ml-1) after 12 weeks of treatment. Triglycerides in the MPPG group were 265.1 mg.100 ml-1 compared to 361.9 mg.100 ml-1. After 12 weeks on MPPG the LDL/HDL ratio of 3.56 was lower than in the placebo group-6.83. Side effects in the MPPG group were similar to those in the placebo group. Thus, MPPG was an effective antihyperlipidaemic agent in patients with renal insufficiency.

References

Oct 1, 1978·European Journal of Clinical Investigation·K BolzanoF Sandhofer
Jun 23, 1977·The New England Journal of Medicine·J D Bagdade, J J Albers
Dec 22, 1977·The New England Journal of Medicine·R MordasiniH Greten
Nov 15, 1979·The New England Journal of Medicine·A P GoldbergE A Nikkila
Apr 1, 1978·European Journal of Clinical Investigation·G Schlierf
Dec 1, 1985·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·B LacourT Drüeke
Apr 26, 1973·The New England Journal of Medicine·E G LowrieJ P Merrill
Jan 5, 1967·The New England Journal of Medicine·D S FredricksonR S Lees
Jan 1, 1971·Annals of Internal Medicine·W B KannelP M McNamara
Jul 25, 1968·The New England Journal of Medicine·J D BagdadeE L Bierman
Oct 1, 1966·Circulation·J W GofmanR Tandy
Jan 1, 1984·Contributions to Nephrology·W F Riesen, R Mordasini
Jan 1, 1980·Atherosclerosis·M L KashyapP S Gartside
May 1, 1980·Atherosclerosis·M ShinomiyaA Kumagai

❮ Previous
Next ❯

Citations

Jan 1, 1989·European Journal of Clinical Pharmacology·R KirstenU Speck
Sep 6, 2005·International Urology and Nephrology·Efstathios MitsopoulosGeorgios Sakellariou
Feb 21, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jeffrey Knox, Barak Gaster
Mar 23, 2007·American Journal of Physiology. Renal Physiology·Maria AnderssonJenny Sörensson Nyström
Apr 9, 2008·Physiological Reviews·Börje HaraldssonWilliam M Deen
Nov 27, 2009·Neurologia Medico-chirurgica·Hitoshi TsuguTooru Inoue
Jul 3, 2018·Journal of Nutritional Science and Vitaminology·Bungo ShirouchiMasao Sato

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.