PMID: 7540058Apr 1, 1995Paper

Magnesium substitution in elective coronary artery surgery: a double-blind clinical study

Journal of Cardiothoracic and Vascular Anesthesia
J O WistbackaA Ruokonen

Abstract

Magnesium may be beneficial in the control of ventricular ectopy and supraventricular tachyarrhythmias after coronary artery bypass graft (CABG) surgery, but it is not known whether a high-dose magnesium regimen is superior to a regimen keeping the patient normomagnesemic. A prospective randomized and double-blind clinical comparison was performed in 81 elective CABG patients in order to assess the effects of two different magnesium infusion regimens on electrolyte balance and postoperative arrhythmias. Forty-one patients (high-dose group, H) received 4.2 +/- 0.7 g (mean +/- SD), of magnesium sulfate before cardiopulmonary bypass, followed by an infusion of 11.9 +/- 2.8 g of magnesium chloride until the first postoperative (PO) morning, and a further 5.5 +/- 1.0 g until the second PO morning. Forty patients (low-dose group, L) received magnesium sulfate only after bypass to a total of 2.9 +/- 0.5 g at the first, and 1.4 +/- 0.1 g at the second PO morning. A blood cardioplegia technique was used in both groups, including bolus doses of magnesium chloride to a total of 2.4 +/- 0.6 g and 2.3 +/- 0.6 g to H and L patients, respectively. Continuous Holter tape-recording was used for 12 to 15 hours preoperatively, and for 48 hours po...Continue Reading

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Citations

Oct 31, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Joel DunningUNKNOWN EACTS Audit and Guidelines Committee
Feb 2, 2000·The Annals of Thoracic Surgery·C W Hogue, M L Hyder
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Dec 3, 2014·Cardiology Clinics·Mrinal YadavaThomas Christopher Crawford
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Sep 11, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Yousef RezaeiSaeid Hosseini

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