Magnesium sulfate exposure increases fetal blood flow redistribution to the brain during acute non-acidemic hypoxemia in goats

Early Human Development
Shigeki TanakaHiroshi Sakamoto

Abstract

It is still controversial that intrapartum exposure to magnesium may or may not reduce brain damage in premature infants in human and animal models. We investigated the effect of hypoxemia alone under magnesium exposure on fetal cardiovascular changes in chronically catheterized goat fetuses. We performed a 3-day experimental protocol with control (10% glucose) on day 1, recovery on day 2, and magnesium on day 3. Magnesium sulfate was directly infused to fetuses in a bolus dose of 270 mg/kg followed by 80 mg/kg/h. Hypoxemia was induced by maternal inhalation of nitrogen gas on day 1 and on day 3. Cerebral blood flow was measured by colored microsphere techniques. Repeated measure ANOVA and Bonferroni's/Dunn's test were used for comparison. Six Japanese Saanen goats at 0.85 gestation. Fetal heart rate, blood pressure, and cerebral blood flow. Ionized magnesium concentrations were significantly increased. Fetal PO2 decreased significantly from 30 mmHg to 14 mmHg without acidemia. Magnesium exposure significantly attenuated hypoxemia-induced bradycardia but did not affect blood pressure. Hypoxemia significantly increased fetal brain blood flow from the pre-hypoxic levels on day 1. Magnesium exposure further increased hypoxemia-ind...Continue Reading

References

Mar 1, 1996·The Journal of Pediatrics·J K GretherS K Cummins
Oct 28, 1998·American Journal of Obstetrics and Gynecology·A OtaT Ikenoue
Jun 18, 2002·American Journal of Obstetrics and Gynecology·Robert MittendorfPaul G Tomich
Dec 4, 2003·JAMA : the Journal of the American Medical Association·Caroline A CrowtherUNKNOWN Australasian Collaborative Trial of Magnesium Sulphate (ACTOMg SO4) Collaborative Group

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Citations

Feb 1, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·E Y ImamogluF Ovali
Mar 28, 2013·Stroke Research and Treatment·Hiroshi Sameshima, Tsuyomu Ikenoue

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