Magnesium Sulfate-Mediated Vascular Relaxation and Calcium Channel Activity in Placental Vessels Different From Nonplacental Vessels

Journal of the American Heart Association
Jiaqi TangZhice Xu

Abstract

Magnesium sulfate (MgSO4) has been used as a common therapy for preeclampsia and eclampsia for many years. MgSO4 decreases peripheral vascular resistance so as to reduce maternal blood pressure. Whether placental blood vessels react to MgSO4 in the same patterns as that in maternal vessels is largely unknown. This study compared placental vessels (PV) versus nonplacental vessels (non-PV) in human and animal models. MgSO4-caused vascular dilation was significantly weaker in PV than that in non-PV. Prostaglandin I2 synthetase affected MgSO4-mediated vasodilatation in PV, not in umbilical vessels, while cyclooxygenase did not influence MgSO4-induced relaxation in both PV and non-PV. Mg2+-caused vasodilatation was mainly through calcium channels. In PV, calcium channel activities were significantly weaker in PV than that in non-PV. Relative mRNA expression of CACNA1D, CACNB2, and CACNB3 was significantly higher in PV than those in umbilical vessels, despite the fact that the expression of CACNA1F was less in PV. The contractile phenotype of smooth muscle cell marker (CALD1) was less and the synthetic phenotype (MYH10) was more in PV than that in UV. These results demonstrated that PV were characterized by much weaker responses to M...Continue Reading

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Citations

Jun 12, 2020·Journal of Veterinary Pharmacology and Therapeutics·Stephen A SchumacherAlicia L Bertone
Sep 10, 2020·Biology of Reproduction·Xueqin FengZhice Xu
Jan 8, 2020·Cell Death & Disease·Sarah M EstradaNicholas Ieronimakis
Jul 29, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xiaolan LiYuanyuan Yang

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BETA
electrophoresis

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GraphPad Prism

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