Magnesium sulfate reduces intra- and postoperative analgesic requirements

Anesthesia and Analgesia
H KoinigN Mayer

Abstract

In a randomized, double-blind study with two parallel groups, we assessed the analgesic effect of perioperative magnesium sulfate administration in 46 ASA physical status I or II patients undergoing arthroscopic knee surgery with total i.v. anesthesia. The patients received either magnesium sulfate 50 mg/kg preoperatively and 8 mg.kg-1.h-1 intraoperatively or the same volume of isotonic sodium chloride solution i.v. Anesthesia was performed with propofol (2 mg/kg for induction, 6-8 mg.kg-1.h-1 for maintenance), fentanyl (3 micrograms/kg for induction), and vecuronium (0.1 mg/kg for intubation). Intraoperative pain was defined as an increase of mean arterial blood pressure and heart rate of more than 20% from baseline values after the induction of anesthesia and was treated with bolus fentanyl (1-2 micrograms/kg). Postoperative analgesia was achieved with fentanyl (0.5 microgram/kg) and evaluated using the pain visual analog scale for 4 h. During the intraoperative and postoperative periods, patients in the magnesium group required significantly less fentanyl than those in the control group (control group 0.089 +/- 0.02 microgram.kg-1.min-1 versus magnesium group 0.058 +/- 0.01 microgram.kg-1.min-1; P < 0.05 and control group 0....Continue Reading

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Citations

Aug 29, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Laurent Dubé, Jean-Claude Granry
Apr 7, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Kemalettin KoltkaSuleyman Ozyalcin
Jun 15, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Perihan EkmekciArif Hikmet Suer
Nov 28, 2012·International Journal of Obstetric Anesthesia·C Dean, J Douglas
Feb 1, 2003·Neuropharmacology·Rashid GiniatullinAndrea Nistri
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Sep 17, 2003·Critical Care : the Official Journal of the Critical Care Forum·Dilek MemişZafer Pamukçu
Oct 1, 2010·Indian Journal of Anaesthesia·Tanmoy GhatakVinod Kumar Bhatia
Jan 1, 2011·International Journal of Pharmaceutical Investigation·V Di StefanoMg Sidoti
Mar 26, 2014·Saudi Journal of Anaesthesia·Akansha AgrawalYashwant S Payal
Apr 17, 2012·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Marzieh-Beigom KhezriSaeid Asefzadeh
Aug 14, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Joon-Ho LeeHee-Cheol Jin
Mar 13, 2012·Anesthesiology Clinics·Adam Young, Asokumar Buvanendran
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Oct 7, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Scott S Reuben, Lakshmi Yalavarthy
Jan 20, 2007·Nihon rinsho. Japanese journal of clinical medicine·Kinomi Yomiya
May 11, 2007·Best Practice & Research. Clinical Anaesthesiology·Asokumar Buvanendran, Jeffrey S Kroin
Dec 11, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Perihan Ergin OzcanFigen Esen
Nov 17, 2006·European Journal of Pharmacology·Parisa HasaneinMajid Ghaseminejad
Mar 22, 2003·Anaesthesia·S M White
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Jul 21, 2004·Journal of Clinical Anesthesia·Anuj BhatiaAnjan Trikha
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Mar 15, 2005·Anesthesiology Clinics of North America·Ashraf S Habib, Tong J Gan
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Aug 7, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·S TugrulO Ozturan
May 9, 2015·Physical Medicine and Rehabilitation Clinics of North America·David Tauben
Dec 17, 2014·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mingjuan TanTong Joo Gan

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