PMID: 9419742Jan 1, 1994Paper

Magnesium sulfate treatment decreases N-methyl-D-aspartate receptor binding in the rat brain: an autoradiographic study

Journal of the Society for Gynecologic Investigation
M HallakD B Cotton

Abstract

We determined the effect of peripherally administered magnesium sulfate on N-methyl-D-aspartate (NMDA) receptor binding capacity in various regions of the rat brain. Three separate experiments were performed. 1) Six rats were injected intraperitoneally with 270 mg/kg of magnesium sulfate, followed by 27 mg/kg every 20 minutes for 4 hours; controls (n = 6) received saline. 2) Six rats received intraperitoneal injections of magnesium sulfate (270 mg/kg) every 4 hours for 24 hours, while six received saline. 3) Six rats received intraperitoneal magnesium sulfate (270 mg/kg) every 12 hours for a total of 2 weeks, and six received saline. Rats were subsequently perfused and sacrificed, and their brains were dissected, rinsed, and frozen. Cryostat sections were taken, labeled by in vitro [3H]-CGP 39653, assayed autoradiographically, and mounted on Ultrofilm for 4 weeks. Optical density measurements of binding on each section were performed using an image analyzing system. Eleven brain regions were sampled: 1, 2) frontal and occipital cortex; 3-7) hippocampus--CA-1, CA-3, stratum radiatum, stratum oriens, dentate gyrus; 8) thalamus; 9) hypothalamus; 10) caudate nucleus; and 11) cerebellum. The NMDA receptor binding density in the hipp...Continue Reading

References

Dec 1, 1992·American Journal of Obstetrics and Gynecology·M HallakD B Cotton
Apr 1, 1992·American Journal of Obstetrics and Gynecology·D B CottonR F Berman
May 1, 1991·Brain Research. Brain Research Reviews·A A Farooqui, L A Horrocks
Aug 1, 1990·Trends in Pharmacological Sciences·R DingledineJ O McNamara
Jan 1, 1990·Life Sciences·B W PeetersA M Coenen
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Dec 1, 1988·Archives of Neurology·P W KaplanD F Hanley
Jan 1, 1986·Clinical Neuropharmacology·J O Donaldson
Apr 1, 1984·American Journal of Obstetrics and Gynecology·J A PritchardS A Pritchard
Mar 1, 1993·American Journal of Obstetrics and Gynecology·D B CottonR F Berman

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Citations

Feb 13, 2009·Stroke; a Journal of Cerebral Circulation·Anna G Euser, Marilyn J Cipolla
Aug 29, 2016·Neurotoxicity Research·Lidawani LambukNafeeza Mohd Ismail
Nov 10, 2007·Gerontology·Asli Ece CillilerSenay Ozbakir
Sep 9, 2018·BMC Pediatrics·Sung-Jin BaekGun-Ha Kim
Mar 7, 2003·Pediatric Research·Osaama H KhanMarc R Del Bigio
Jun 29, 2011·Fetal and Maternal Medicine Review·Marilyn J Cipolla, Richard P Kraig
Apr 25, 2017·The Western Journal of Emergency Medicine·Eric C SilvermanGreg H Gilbert
Sep 28, 2020·American Journal of Obstetrics and Gynecology·Michal Fishel Bartal, Baha M Sibai
Jan 18, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·M S MebazaaM S Ben Ammar

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