Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study

Journal of Pregnancy
Maria BullarboThorkild Nielsen

Abstract

To investigate the effect of magnesium (Mg) supplementation in healthy pregnant women for prevention of blood pressure increase. Secondary outcomes were comparison of biomarkers for hypertensive disorders and labour and fetal outcomes between the groups. Two hundred nulliparous healthy pregnant women were double-blind randomized to receive Mg daily or placebo. There were no differences in blood pressure increase. However, among the Mg-treated women, there was a significant negative correlation between increase in blood levels of magnesium and increase in systolic blood pressure (p = 0.042). Magnesium supplementation seems to be safe for both mother and infant. Magnesium supplementation in healthy first-time pregnant women is not to be recommended for prevention of blood pressure increase. Supplementation in risk pregnancies needs to be further investigated. The study is listed on the ISRCTN registry with study ID 13890849.

References

Jul 1, 1989·American Journal of Obstetrics and Gynecology·B M SibaiE Bray
Jun 15, 2006·American Journal of Epidemiology·Lisa M BodnarJames M Roberts
Jan 18, 2007·Molecular Human Reproduction·Karl KristensenS R Hansson
May 31, 2007·The Journal of Clinical Endocrinology and Metabolism·Lisa M BodnarJames M Roberts
Jul 27, 2007·Acta Obstetricia Et Gynecologica Scandinavica·K KristensenA Grubb
Jan 2, 2008·American Journal of Obstetrics and Gynecology·Shi Wu WenMark C Walker
Dec 17, 2008·Placenta·J M Roberts, C A Hubel
Jan 19, 2010·Annual Review of Pathology·Brett C YoungS Ananth Karumanchi
Feb 6, 2010·Archives of Gynecology and Obstetrics·Thorkild F Nielsen, Ragnar Rylander
Dec 22, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Deniz Cemgil ArikanAli Ozer
Dec 27, 2011·Placenta·U D AndersonS R Hansson
Feb 10, 2012·European Journal of Clinical Nutrition·L KassL Carpenter
May 30, 2013·Archives of Gynecology and Obstetrics·Maria BullarboRagnar Rylander
Apr 4, 2014·The Cochrane Database of Systematic Reviews·Maria MakridesCaroline A Crowther
Sep 23, 2014·Archives of Gynecology and Obstetrics·Maria Bullarbo, Ragnar Rylander
Jan 1, 2014·Pregnancy Hypertension·Axel NestlerMaria Bullarbo
Apr 1, 2014·Pregnancy Hypertension·Ragnar Rylander
Sep 20, 2016·American Journal of Obstetrics and Gynecology·Stéphanie RobergeEmmanuel Bujold
Apr 17, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Oluwatobiloba OsikoyaStyliani Goulopoulou
Apr 30, 2017·American Journal of Obstetrics and Gynecology·Mary Catherine TolcherKjersti M Aagaard
Jun 29, 2017·The New England Journal of Medicine·Daniel L RolnikKypros H Nicolaides
Jul 16, 2017·BMC Pregnancy and Childbirth·Juhi M PurswaniSaurabh Mehta
Nov 25, 2017·Metabolism: Clinical and Experimental·C AntzaV Kotsis

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Citations

Apr 11, 2020·BMC Pregnancy and Childbirth·Carla Adriane Leal de AraújoJoão Guilherme Bezerra Alves
Mar 31, 2021·The Journal of Obstetrics and Gynaecology Research·Keizo Kanasaki, Asako Kumagai
Sep 9, 2021·The Journal of Nutrition·Katherine A SauderUNKNOWN Program Collaborators for Environmental influences on Child Health Outcomes (ECHO)

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