PMID: 8961243Dec 1, 1996Paper

Magnesium taurate and fish oil for prevention of migraine

Medical Hypotheses
M F McCarty

Abstract

Although the pathogenesis of migraine is still poorly understood, various clinical investigations, as well as consideration of the characteristic activities of the wide range of drugs known to reduce migraine incidence, suggest that such phenomena as neuronal hyperexcitation, cortical spreading depression, vasospasm, platelet activation and sympathetic hyperactivity often play a part in this syndrome. Increased tissue levels of taurine, as well as increased extracellular magnesium, could be expected to dampen neuronal hyperexcitation, counteract vasospasm, increase tolerance to focal hypoxia and stabilize platelets; taurine may also lessen sympathetic outflow. Thus it is reasonable to speculate that supplemental magnesium taurate will have preventive value in the treatment of migraine. Fish oil, owing to its platelet-stabilizing and antivasospastic actions, may also be useful in this regard, as suggested by a few clinical reports. Although many drugs have value for migraine prophylaxis, the two nutritional measures suggested here may have particular merit owing to the versatility of their actions, their safety and lack of side-effects and their long-term favorable impact on vascular health.

References

Jul 1, 1977·Headache·D F Horrobin
Nov 1, 1979·Prostaglandins and Medicine·K L BlackW E Lands
Jul 1, 1975·Headache·M A Pollack, J H French
Nov 15, 1992·The American Journal of Cardiology·D KennyB M Egan
Jan 1, 1991·Journal of Cardiovascular Pharmacology·H P Ludin
Jan 1, 1991·Fundamental & Clinical Pharmacology·M T Ristori, J Verdetti
Oct 3, 1990·JAMA : the Journal of the American Medical Association·J E BuringC H Hennekens
Jan 1, 1986·Clinical Neuropharmacology·D A Greenberg
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S Finkbeiner, C F Stevens
Jan 1, 1989·Preventive Medicine·B S Kendler
Sep 1, 1989·Stroke; a Journal of Cerebral Circulation·M Sadeh
Jul 1, 1989·Headache·N M RamadanK M Welch
Jan 1, 1988·Perspectives in Biology and Medicine·D R Swanson
Oct 1, 1988·Acta Neurologica Scandinavica·K V Sørensen
Nov 3, 1988·The New England Journal of Medicine·R S Goldman, S M Finkbeiner
Jul 1, 1987·Headache·R Joseph, K M Welch
Sep 1, 1986·Headache·E Hanington
Sep 1, 1985·Neurology·K M WelchP A Keenan
Apr 1, 1972·Neurology·R B Weber, O M Reinmuth
Oct 3, 1981·Lancet·E HaningtonB Wachowicz
Mar 1, 1983·Clinical Neuropharmacology·L Durelli, R Mutani
Jul 1, 1984·Stroke; a Journal of Cerebral Circulation·F X Vacanti, A Ames
Apr 29, 1983·Science·S M Rothman
Apr 1, 1982·British Journal of Pharmacology·F FranconiL Zilletti
Nov 11, 1993·The New England Journal of Medicine·K M Welch
Aug 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P Puig-ParelladaJ Obach

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Citations

Jan 8, 2005·Journal of the American College of Nutrition·Paul J PorrMargareta Rusu
Aug 24, 1999·Pharmacotherapy·K W WeitzelJ V Goode
Apr 4, 2002·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Ranko RaicevićNatasa Vukotiç
May 21, 2009·The Clinical Journal of Pain·Christina Sun-Edelstein, Alexander Mauskop
Sep 14, 2000·Medical Hypotheses·A L Russell, M F McCarty

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