Magnetic aerosol drug targeting in lung cancer therapy using permanent magnet

Drug Delivery
Mohammad K D ManshadiAmir Sanati-Nezhad

Abstract

Primary bronchial cancer accounts for almost 20% of all cancer death worldwide. One of the emerging techniques with tremendous power for lung cancer therapy is magnetic aerosol drug targeting (MADT). The use of a permanent magnet for effective drug delivery in a desired location throughout the lung requires extensive optimization, but it has not been addressed yet. In the present study, the possibility of using a permanent magnet for trapping the particles on a lung tumor is evaluated numerically in the Weibel's model from G0 to G3. The effect of different parameters is considered on the efficiency of particle deposition in a tumor located on a distant position of the lung bronchi and bronchioles. Also, the effective position of the magnetic source, tumor size, and location are the objectives for particle deposition. The results show that a limited particle deposition occurs on the lung branches in passive targeting. However, the incorporation of a permanent magnet next to the tumor enhanced the particle deposition fraction on G2 to up to 49% for the particles of 7 µm diameter. Optimizing the magnet size could also improve the particle deposition fraction by 68%. It was also shown that the utilization of MADT is essential for e...Continue Reading

References

May 20, 2003·Journal of Biomechanical Engineering·C Kleinstreuer, Z Zhang
Nov 19, 2004·Nature·Charles Sawyers
May 15, 2007·Journal of Biomechanics·H Y LuoX L Yang
Jul 26, 2008·Nature Nanotechnology·Petra DamesCarsten Rudolph
Feb 25, 2009·Expert Opinion on Drug Delivery·Boris Polyak, Gary Friedman
Mar 12, 2009·Health Physics·UNKNOWN International Commission on Non-Ionizing Radiation Protection
Aug 12, 2009·Expert Opinion on Drug Delivery·Jair BarAmir Onn
Mar 4, 2010·Pharmaceutical Research·Yuanyuan XieP Worth Longest
Sep 17, 2010·Journal of Pharmaceutical Sciences·Yuanyuan XieTimothy Scott Wiedmann
Jul 1, 2011·The Korean Journal of Internal Medicine·Seon-Heui LeeKwang-Joo Park
Jan 25, 2013·Journal of Nanobiotechnology·Navin Kumar VermaYurii K Gun'ko
Dec 7, 2013·Biotechnology Advances·Juan LiuXing-Jie Liang
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Nov 8, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Benjamin ShapiroIrving N Weinberg
Apr 22, 2015·The New England Journal of Medicine·Edward B GaronUNKNOWN KEYNOTE-001 Investigators
May 15, 2015·Journal of Biomechanical Engineering·Katrin Bauer, Christoph Brücker
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 18, 2016·Biomechanics and Modeling in Mechanobiology·Oveis PourmehranMofid Gorji-Bandpy
Jan 1, 2015·Nature Reviews. Disease Primers·Cesare GridelliRafael Rosell
Aug 23, 2016·International Journal of Nanomedicine·Yan OstrovskiJosué Sznitman
Sep 7, 2016·International Journal for Numerical Methods in Biomedical Engineering·Ana F TenaD Keith Walters
Apr 5, 2017·Medical Engineering & Physics·Antonio F Miguel
Aug 11, 2017·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Shuai RenWeiqing Xu
Oct 27, 2017·Molecular Pharmaceutics·Dominique N PricePavan Muttil
Nov 15, 2017·Proceedings of the National Academy of Sciences of the United States of America·Tao SunNathan J McDannold
Jan 30, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hassan Pezeshgi ModarresAmir Sanati-Nezhad
Jan 30, 2018·Biotechnology Advances·Shirin SoleimaniAmir Sanati-Nezhad
Mar 29, 2018·Drug Delivery·Milad ShamsiAmir Sanati-Nezhad
Jun 13, 2018·Scientific Reports·Milad ShamsiAmir Sanati-Nezhad

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Citations

Nov 28, 2020·Physics of Fluids·Arnab Kumar MallikMahesh V Panchagnula
Feb 6, 2021·Journal of Biomechanics·Yan OstrovskiJosué Sznitman
Sep 14, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mahsa SaadatAmir Sanati-Nezhad
Apr 13, 2021·Biosensors & Bioelectronics·Mehdi MohammadiAmir Sanati-Nezhad

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Software Mentioned

MADT
COMSOL Multiphysics

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