Magnetic core mesoporous silica nanoparticles doped with dacarbazine and labelled with 99mTc for early and differential detection of metastatic melanoma by single photon emission computed tomography

Artificial Cells, Nanomedicine, and Biotechnology
Filipe Leal PortilhoRalph Santos-Oliveira

Abstract

Cancer is responsible for more than 12% of all causes of death in the world, with an annual death rate of more than 7 million people. In this scenario melanoma is one of the most aggressive ones with serious limitation in early detection and therapy. In this direction we developed, characterized and tested in vivo a new drug delivery system based on magnetic core-mesoporous silica nanoparticle that has been doped with dacarbazine and labelled with technetium 99 m to be used as nano-imaging agent (nanoradiopharmaceutical) for early and differential diagnosis and melanoma by single photon emission computed tomography. The results demonstrated the ability of the magnetic core-mesoporous silica to be efficiently (>98%) doped with dacarbazine and also efficiently labelled with 99mTc (technetium 99 m) (>99%). The in vivo test, using inducted mice with melanoma, demonstrated the EPR effect of the magnetic core-mesoporous silica nanoparticles doped with dacarbazine and labelled with technetium 99 metastable when injected intratumorally and the possibility to be used as systemic injection too. In both cases, magnetic core-mesoporous silica nanoparticles doped with dacarbazine and labelled with technetium 99 metastable showed to be a rel...Continue Reading

References

Apr 17, 2013·Artificial Cells, Nanomedicine, and Biotechnology·Marta de Souza AlbernazRalph Santos-Oliveira
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Nov 22, 2014·Science·Jennifer A Lo, David E Fisher
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
May 1, 2014·World Journal of Obstetrics and Gynecology·Sherri L StewartCheryll C Thomas
Mar 18, 2016·Oncology Reports·Monica NeaguAristidis M Tsatsakis
Feb 1, 2017·Trends in Cancer·Barbara K Dunn, Barnett S Kramer
Feb 18, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Cristal Cerqueira-CoutinhoRalph Santos-Oliveira
Mar 2, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michael G KempJeffrey B Travers
Mar 31, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Roberto SalviRalph Santos-Oliveira
Jun 1, 2017·American Society of Clinical Oncology Educational Book·Kimberly M KomatsubaraAxel Hauschild
Aug 27, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Lluis PascualFélix Sancenón
Sep 10, 2017·Dermatologic Clinics·Alex M GlazerAaron S Farberg
Oct 25, 2017·Pharmaceutical Research·Thiago Goulart RosaRalph Santos-Oliveira

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Citations

Apr 3, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Chengwei ZhangHongqian Guo
Apr 25, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Legha AnsariBizhan Malaekeh-Nikouei
Feb 23, 2019·International Journal of Molecular Sciences·Rafael R Castillo, María Vallet-Regí
Aug 15, 2019·Nanomedicine·Francisco ArriagadaJavier Morales
Aug 20, 2019·Current Pharmaceutical Design·Julio Cezar de Almeida JuniorRalph Santos-Oliveira
Feb 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana-Maria PutzCristina Dehelean
Jan 8, 2020·International Journal of Molecular Sciences·Edward Helal-NetoRalph Santos-Oliveira

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