Magnetic Detection Structure for Lab-on-Chip Applications Based on the Frequency Mixing Technique

Sensors
Amine RabehiHamid Kokabi

Abstract

A magnetic frequency mixing technique with a set of miniaturized planar coils was investigated for use with a completely integrated Lab-on-Chip (LoC) pathogen sensing system. The system allows the detection and quantification of superparamagnetic beads. Additionally, in terms of magnetic nanoparticle characterization ability, the system can be used for immunoassays using the beads as markers. Analytical calculations and simulations for both excitation and pick-up coils are presented; the goal was to investigate the miniaturization of simple and cost-effective planar spiral coils. Following these calculations, a Printed Circuit Board (PCB) prototype was designed, manufactured, and tested for limit of detection, linear response, and validation of theoretical concepts. Using the magnetic frequency mixing technique, a limit of detection of 15 µg/mL of 20 nm core-sized nanoparticles was achieved without any shielding.

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Citations

Apr 30, 2020·Electrophoresis·Sumera KhizarAbdelhamid Elaissari
Nov 2, 2019·Micromachines·Eriola-Sophia ShankoJaap M J den Toonder
May 25, 2021·Nanomedicine·Smriti Sharma, Vinayak Bhatia
Jul 31, 2021·Journal of Healthcare Engineering·Yuxing ShiWenhao Zhao

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Methods Mentioned

BETA
nuclear magnetic resonance
biosensing
biosensors
transmission electron microscopy

Software Mentioned

COMSOL Multiphysics

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