Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy.

Nature Communications
Bo YuDong-Hyun Kim

Abstract

We report a strategy to boost Fenton reaction triggered by an exogenous circularly polarized magnetic field (MF) to enhance ferroptosis-like cell-death mediated immune response, as well as endow a responsive MRI capability by using a hybrid core-shell vesicles (HCSVs). HCSVs are prepared by loading ascorbic acid (AA) in the core and poly(lactic-co-glycolic acid) shell incorporating iron oxide nanocubes (IONCs). MF triggers the release of AA, resulting in the increase of ferrous ions through the redox reaction between AA and IONCs. A significant tumor suppression is achieved by Fenton reaction-mediated ferroptosis-like cell-death. The oxidative stress induced by the Fenton reaction leads to the exposure of calreticulin on tumor cells, which leads to dendritic cells maturation and the infiltration of cytotoxic T lymphocytes in tumor. Furthermore, the depletion of ferric ions during treatment enables monitoring of the Fe reaction in MRI-R2* signal change. This strategy provides a perspective on ferroptosis-based immunotherapy.

References

Oct 11, 2008·Cell Death and Differentiation·G KroemerUNKNOWN Nomenclature Committee on Cell Death 2009
Dec 17, 2008·Environmental Science & Technology·Christopher K DuesterbergT David Waite
May 29, 2012·Cell·Scott J DixonBrent R Stockwell
Jun 26, 2012·Biochimica Et Biophysica Acta·Juan DuGarry R Buettner
Jun 19, 2013·The Journal of Investigative Dermatology·Yajun ZhangTianwen Gao
Jan 21, 2014·Cell·Wan Seok YangBrent R Stockwell
Feb 25, 2014·Nature Reviews. Cancer·Katrina F Chu, Damian E Dupuy
Nov 8, 2015·Advanced Drug Delivery Reviews·Quanyin HuZhen Gu
Jan 23, 2016·Cell Death and Differentiation·Y XieD Tang
Apr 2, 2017·Trends in Pharmacological Sciences·Jose Pedro Friedmann AngeliMarcus Conrad
Apr 14, 2017·ACS Applied Materials & Interfaces·Wooram ParkDong-Hyun Kim
Jan 23, 2018·Advanced Materials·Zheyu ShenXiaoyuan Chen
Oct 27, 2018·Journal of Imaging·Dong-Hyun Kim
Jan 22, 2019·Advanced Materials·Qian ChenZhuang Liu
Apr 17, 2019·ACS Nano·Wilson PoonWarren C W Chan
Aug 1, 2017·Nature Biomedical Engineering·Abdullah Muhammad SyedWarren C W Chan
Oct 28, 2019·Journal of Vascular and Interventional Radiology : JVIR·Monica M MatsumotoSamdeep K Mouli

❮ Previous
Next ❯

Citations

Nov 3, 2020·Advanced Healthcare Materials·Hung-Wei ChengSan-Yuan Chen
Apr 2, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Haiyan WangYongguang Tao
Nov 21, 2020·Cell Metabolism·Jiashuo Zheng, Marcus Conrad
May 1, 2021·Pharmaceutics·Kwang-Soo KimDong-Hyun Kim
May 11, 2021·Frontiers in Chemistry·Yingbo LiXilin Sun
May 18, 2021·Frontiers in Cell and Developmental Biology·Haiyang WuZhiming Sun
Jun 4, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xuexin LiZehuan Liao
Jun 26, 2021·ACS Applied Materials & Interfaces·Xiao CuiChun-Sing Lee
Jun 17, 2021·Biochemical and Biophysical Research Communications·Wenwen SiMeiling Zhu
Jul 28, 2021·Trends in Molecular Medicine·Huanji XuFeng Bi
Sep 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qun GuanYu-Bin Dong

❮ Previous
Next ❯

Methods Mentioned

BETA
Flow
Flow cytometry
MDA

Software Mentioned

R Studio
ImageJ
AxioVision Microscope

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Molecular & Cellular Oncology
Megan Conlon, Scott J Dixon
Science Signaling
Alexandra A Mushegian
The Journal of Cell Biology
Ayelén Mariana DistéfanoGabriela Carolina Pagnussat
© 2021 Meta ULC. All rights reserved