PMID: 3771156Sep 1, 1986Paper

Magnetic field dependence (NMRD profile) of 1/T1 of rabbit kidney medulla and urine after intravenous injection of Gd(DTPA)

Investigative Radiology
S H KoenigG L Wolf

Abstract

The measurement of NMRD profiles of water protons of excised tissues containing paramagnetic metal ions is one of the few ways of determining the biochemical and biophysical state of these ions in vivo. It is of critical importance, for example, to verify that Gd, injected as Gd(DTPA) to enhance contrast in MRI, remains chelated, since free Gd ions are highly toxic. We have investigated this in the renal medulla of rabbits. Fitting the magnetization data at each field of the dispersion to a single exponential shows that Gd accumulates predominantly in the renal medulla, from which it is cleared within 18 hours, and that Gd(DTPA) introduced intravenously into rabbits is excreted as Gd(DTPA) in the urine as rotationally mobile as in neat water. Taking a larger data set at each field and fitting it to the sum of two exponentials, since the errors of the single exponential analysis were larger than for other tissues, shows that the relaxation behavior of the renal medulla, free of contrast agent, can be well-described by a single relaxation rate at 37 degrees C. For increasing concentrations of Gd in the medulla, as determined by ICP analysis, two relaxation rates are required to account for the data, due to compartmentalization of...Continue Reading

Citations

Jan 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H PaajanenM Kormano
Jul 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M A MartinR L Armstrong
Jan 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·I K Adzamli, M Blau
Dec 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M F TweedleS M Eaton
Nov 1, 1991·Bioconjugate Chemistry·G Hernández, R G Bryant
Oct 1, 1987·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P Gillis, S H Koenig
Jul 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P NiemiM Kormano
Nov 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M SpillerG L Wolf
Dec 24, 1997·Investigative Radiology·M F TweedleH W Strauss
Apr 19, 2005·Magnetic Resonance Imaging·Robert G Bryant, Jean-Pierre Korb

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