Magnetic field exposure saves rat cerebellar granule neurons from apoptosis in vitro

Neuroscience Letters
Tsuyoshi Oda, Tatsuro Koike

Abstract

Accumulating evidence demonstrates that extremely low frequency magnetic fields (ELF-MFs) are capable of modifying neuronal function. Here we examine the effect of ELF-MF exposure on neuronal apoptosis. For this purpose cerebellar granule neurons (CGNs) from postnatal rats were employed, which are known to undergo apoptosis under normal condition (5.4 mM K+) in vitro. Exposure to a rotating (50 Hz) ELF-MF for 5 days saved immature CGNs from apoptosis and promoted survival at the flux density of 300 mT, whereas virtually no neuronal survival was observed without exposure (sham). The survival-promoting effect of ELF-MFs occurred in a manner that depended on the size of culture flasks, suggesting that induced current plays a role in this phenomenon. A maximal survival-promoting effect was comparable to that of membrane depolarization (25 mM K+) and greater than that of brain-derived neurotrophic factor (BDNF). These results imply that ELF-MFs may serve as a potential tool for manipulating neuronal death and/or survival.

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Citations

Feb 14, 2014·Journal of Neuroscience Research·Rukmani LekhrajDiana Casper
Jan 3, 2014·The European Journal of Neuroscience·Maria V PoddaClaudio Grassi
Aug 31, 2014·Neuroscience·M Ben Yakir-BlumkinJ P M Finberg

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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