Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering

Frontiers in Bioengineering and Biotechnology
Sena YamanH Cumhur Tekin

Abstract

Live cell manipulation is an important biotechnological tool for cellular and tissue level bioengineering applications due to its capacity for guiding cells for separation, isolation, concentration, and patterning. Magnetic force-based cell manipulation methods offer several advantages, such as low adverse effects on cell viability and low interference with the cellular environment. Furthermore, magnetic-based operations can be readily combined with microfluidic principles by precisely allowing control over the spatiotemporal distribution of physical and chemical factors for cell manipulation. In this review, we present recent applications of magnetic force-based cell manipulation in cellular and tissue bioengineering with an emphasis on applications with microfluidic components. Following an introduction of the theoretical background of magnetic manipulation, components of magnetic force-based cell manipulation systems are described. Thereafter, different applications, including separation of certain cell fractions, enrichment of rare cells, and guidance of cells into specific macro- or micro-arrangements to mimic natural cell organization and function, are explained. Finally, we discuss the current challenges and limitations ...Continue Reading

References

Sep 1, 1971·Biophysical Journal·H A Pohl, J S Crane
Dec 16, 1998·Immunotechnology : an International Journal of Immunological Engineering·A ThielA Radbruch
Jun 27, 2000·Biophysical Journal·C M LoY L Wang
Apr 2, 2003·Biophysical Journal·Maciej ZborowskiAlan N Schechter
Aug 15, 2003·Nature·David G Grier
Aug 21, 2004·Breast Cancer Research : BCR·Valérie ChoesmelNathalie Blin
Nov 2, 2004·Angiogenesis·Nicholas E TimminsLars K Nielsen
Dec 21, 2004·Nature Biotechnology·Mark M WangWilliam F Butler
Mar 1, 2005·Analytical Chemistry·Filip PeterssonThomas Laurell
Mar 19, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Tsunehisa KimuraAkihiro Nara
Apr 16, 2005·Bioelectromagnetics·Alfonsina ChionnaLuciana Dini
Jul 14, 2005·Biomaterials·Joseph YangTeruo Okano
Jul 22, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Scott L NybergPiero Rinaldo
Oct 26, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kazunori ShimizuHiroyuki Honda
Dec 24, 2005·Lab on a Chip·Nicole Pamme
Feb 24, 2006·Chemical Communications : Chem Comm·Hongwei GuBing Xu
Mar 15, 2006·Biosensors & Bioelectronics·Ki-Ho HanA Bruno Frazier
Jul 13, 2006·Annual Review of Biomedical Engineering·Joel Voldman
Jul 28, 2006·Nature·Jamil El-AliKlavs F Jensen
Jul 29, 2006·Lab on a Chip·Nicole Pamme, Claire Wilhelm
Jan 12, 2007·Biotechnology and Bioengineering·Kosuke InoHiroyuki Honda
Feb 7, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kazunori ShimizuHiroyuki Honda
Feb 28, 2007·Chemical Society Reviews·Thomas LaurellAndreas Nilsson
Mar 21, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Mandana VeisehMiqin Zhang
Apr 7, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Xuanhong ChengWilliam R Rodriguez
Jun 16, 2007·Analytical Chemistry·Filip PeterssonThomas Laurell
Apr 29, 1966·Science·H A Pohl, I Hawk
Oct 5, 2007·Biomedical Microdevices·Hong Miao JiLevent Yobas
Oct 30, 2007·Journal of Bioscience and Bioengineering·Kazunori ShimizuHiroyuki Honda
Dec 19, 2007·Journal of Bioscience and Bioengineering·Akira ItoMasamichi Kamihira
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mikako SasakiHiroshi Shimizu

❮ Previous
Next ❯

Citations

Apr 26, 2019·Stem Cells and Development·Ana-Maria SeciuOtilia Zarnescu
Dec 12, 2019·Advanced Materials·Vítor M GasparJoão F Mano
Nov 13, 2019·Angewandte Chemie·Christoffer K AbrahamssonGeorge M Whitesides
Jun 6, 2019·Angewandte Chemie·Shencheng GeGeorge M Whitesides
Apr 30, 2020·Electrophoresis·Sumera KhizarAbdelhamid Elaissari
May 21, 2020·Micromachines·Adar HacohenOrit Shefi
May 22, 2019·Frontiers in Bioengineering and Biotechnology·Francisco Tovar-LopezSara Baratchi
Oct 20, 2020·Analytical Methods : Advancing Methods and Applications·Zachary D CallCharles S Henry
Nov 19, 2020·Biotechnology and Bioengineering·Oyku SarigilEngin Ozcivici
Feb 5, 2021·Lab on a Chip·Yuyang LiTatsuo Arai
Mar 2, 2021·ACS Applied Materials & Interfaces·Yinling ChenXiaoxi Liu
Nov 7, 2020·Physical Chemistry Chemical Physics : PCCP·S D BorisovaE V Chulkov
Apr 16, 2021·Nanotechnology, Science and Applications·Peter BlümlerVolker Mailänder
May 15, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Lisa BelfioreMartin Engel
Aug 20, 2020·Analytical Chemistry·Sena Yaman, H Cumhur Tekin
Aug 31, 2021·Frontiers in Cell and Developmental Biology·Long PangShih-Kang Fan

❮ Previous
Next ❯

Methods Mentioned

BETA
magnetically-activated cell sorting
chip
fluorescence
fluorescence microscopy
fluorescence-activated cell sorting
flow cytometry
FACS
bioprinting

Software Mentioned

MagLev
MagDense

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Biotechnology
Matthias Mehling, Savaş Tay
Progress in Molecular Biology and Translational Science
Akira Ito, Masamichi Kamihira
© 2021 Meta ULC. All rights reserved