Magnetic Glycol Chitin-Based Hydrogel Nanocomposite for Combined Thermal and d-Amino-Acid-Assisted Biofilm Disruption

ACS Infectious Diseases
Eric C AbenojarAnna Cristina S Samia

Abstract

Bacterial biofilms are highly antibiotic resistant microbial cell associations that lead to chronic infections. Unlike free-floating planktonic bacterial cells, the biofilms are encapsulated in a hardly penetrable extracellular polymeric matrix and, thus, demand innovative approaches for treatment. Recent advancements on the development of gel-nanocomposite systems with tailored therapeutic properties provide promising routes to develop novel antimicrobial agents that can be designed to disrupt and completely eradicate preformed biofilms. In our study, we developed a unique thermoresponsive magnetic glycol chitin-based nanocomposite containing d-amino acids and iron oxide nanoparticles, which can be delivered and undergoes transformation from a solution to a gel state at physiological temperature for sustained release of d-amino acids and magnetic field actuated thermal treatment of targeted infection sites. The d-amino acids in the hydrogel nanocomposite have been previously reported to inhibit biofilm formation and also disrupt existing biofilms. In addition, loading the hydrogel nanocomposite with magnetic nanoparticles allows for combination thermal treatment following magnetic field (magnetic hyperthermia) stimulation. Usi...Continue Reading

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Citations

Apr 15, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Leah H CobbLauren B Priddy
Jun 4, 2020·Pharmaceutics·Atanu Naskar, Kwang-Sun Kim
Mar 6, 2021·ACS Biomaterials Science & Engineering·Zhen GuoYi Zhang
Feb 23, 2021·Frontiers in Chemistry·Yanyu Zhang, Yishun Huang
Jun 3, 2021·Tropical Medicine and Infectious Disease·Pier Francesco IndelliGennaro Pipino
Jul 22, 2021·APL Bioengineering·Daqian GaoMinglin Ma

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