Magnetic induction heating of superparamagnetic nanoparticles during rewarming augments the recovery of hUCM-MSCs cryopreserved by vitrification

Acta Biomaterialia
Jianye WangXiaoming He

Abstract

Cryopreservation by vitrification has been recognized as a promising strategy for long-term banking of living cells. However, the difficulty to generate a fast enough heating rate to minimize devitrification and recrystallization-induced intracellular ice formation during rewarming is one of the major obstacles to successful vitrification. We propose to overcome this hurdle by utilizing magnetic induction heating (MIH) of magnetic nanoparticles to enhance rewarming. In this study, superparamagnetic (SPM) Fe3O4 nanoparticles were synthesized by a chemical coprecipitation method. We successfully applied the MIH of Fe3O4 nanoparticles for rewarming human umbilical cord matrix mesenchymal stem cells (hUCM-MSCs) cryopreserved by vitrification. Our results show that extracellular Fe3O4 nanoparticles with MIH may efficiently suppress devitrification and/or recrystallization during rewarming and significantly improve the survival of vitrified cells. We further optimized the concentration of Fe3O4 nanoparticles and the current of an alternating current (AC) magnetic field for generating the MIH to maximize cell viability. Our results indicate that MIH in an AC magnetic field with 0.05% (w/v) Fe3O4 nanoparticles significantly facilitates...Continue Reading

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Citations

Sep 3, 2020·Advanced Healthcare Materials·Zonghu HanJohn C Bischof
Jun 12, 2020·Biopreservation and Biobanking·Xiaozhang ZhangGang Zhao
Jan 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lingxiao ShenGang Zhao
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Feb 6, 2017·Biotechnology Advances·Gang Zhao, Jianping Fu
Mar 23, 2021·Advanced Science·Tie Chang, Gang Zhao
Aug 25, 2021·Nature Biomedical Engineering·Haishui HuangMartin L Yarmush
Oct 14, 2019·ACS Biomaterials Science & Engineering·Yufang LiGang Zhao
Jul 10, 2021·Trends in Biotechnology·Mengjia DouWei Rao

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