Magnetic NGF-releasing PLLA/iron oxide nanoparticles direct extending neurites and preferentially guide neurites along aligned electrospun microfibers

ACS Chemical Neuroscience
Jonathan M ZuidemaR J Gilbert

Abstract

Nerve growth factor releasing composite nanoparticles (NGF-cNPs) were developed to direct the extension of neurite outgrowth from dorsal root ganglia (DRG). Iron oxide magnetic nanoparticles were incorporated into poly-l-lactic acid (PLLA) nanoparticles in order to position the NGF-cNPs in a culture dish. Neurites growing from DRG extended toward the NGF released from the NGF-cNPs. DRG were then cultured on aligned PLLA microfibers in the presence of NGF-cNPs, and these biomaterials combined to align DRG neurite extension along one axis and preferentially toward the NGF-cNPs. This combinatorial biomaterial approach shows promise as a strategy to direct the extension of regenerating neurites.

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Citations

Dec 19, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Neta ZilonyEster Segal
Mar 9, 2018·MRS Communications·Radamés Ayala-CamineroJorge Almodovar
Feb 14, 2018·Expert Opinion on Biological Therapy·Jakub SmolarDaniel Eberli
May 24, 2018·Nanomedicine·Chen AijieShao Longquan
May 26, 2017·Frontiers in Pharmacology·Alexis M Ziemba, Ryan J Gilbert
Jun 11, 2019·Frontiers in Bioengineering and Biotechnology·Milad Fathi-AchacheloueiNihal Engin Vrana
Jan 16, 2020·Polymers·Angelika ZaszczynskaArkadiusz Gradys
Jun 1, 2018·World Journal of Stem Cells·Luminita LabuscaKaveh Mashayekhi
Sep 12, 2018·Nanomaterials·Michal MarcusOrit Shefi
Aug 14, 2019·Frontiers in Bioengineering and Biotechnology·Jessica L FunnellRyan J Gilbert

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