Magnetic norbornene polymer as multiresponsive nanocarrier for site specific cancer therapy

Bioconjugate Chemistry
Vijayakameswara Rao NRaja Shunmugam

Abstract

A site-specific, stimuli-responsive nanocarrier has been synthesized by conjugating folate, magnetic particles and doxorubicin to the backbone of norbornene polymer. Monomers, namely, cis-5-norbornene-6-(diethoxyphosphoryl)hexanote (mono 1), norbornene grafted poly(ethyleneglycol)-folate (mono 2), and norbornene derived doxorubicin (mono 3) are carefully designed to demonstrate the smart nanorcarrier capabilities. The synthesis and complete characterization of all three monomers are elaborately discussed. Their copolymerization is done by controlled/living ring-opening metathesis polymerization (ROMP) to get the triblock copolymer PHOS-FOL-DOX. NMR spectroscopy and gel permeation chromatography confirm the formation of the triblock copolymer, while FT-IR spectroscopy, thermogravimetric analysis, along with transmission electron microscope confirm the anchoring of iron particle (Fe3O4) to the PHOS-FOL-DOX. Drug release profile shows the importance of having the hydrazone linker that helps to release the drug exactly at the mild acidic conditions resembling the pH of the cancerous cells. The newly designed nanocarrier shows greater internalization (about 8 times) due to magnetic field. Also, increased intracellular DOX release is...Continue Reading

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Citations

Nov 13, 2015·Journal of Drug Targeting·Minglu ChangWei Shao
Dec 15, 2015·Expert Opinion on Drug Delivery·N Vijayakameswara RaoJae Hyung Park
Aug 19, 2014·Bioconjugate Chemistry·Ailing FuVincent M Rotello
Feb 23, 2017·Advanced Materials·Fangyuan LiDaishun Ling
Mar 3, 2020·Expert Opinion on Drug Delivery·Yijie SongNing Zhang
Sep 23, 2014·Chemical Communications : Chem Comm·Vijayakameswara Rao NRaja Shunmugam
Aug 31, 2018·Frontiers in Bioengineering and Biotechnology·N Vijayakameswara RaoJae Hyung Park
Oct 4, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Seyed Hassan HosseiniNasrin Zohreh

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