Magnetic Oleosome as a Functional Lipophilic Drug Carrier for Cancer Therapy

ACS Applied Materials & Interfaces
Hyeon-Yeol ChoJeong-Woo Choi

Abstract

In the present study, we fabricated magnetic oleosomes functionalized with recombinant proteins as a new carrier for oil-based lipophilic drugs for cancer treatment. The bioengineered oleosome is composed of neutral lipids surrounded by a phospholipid monolayer with embedded oleosin fusion proteins. The oleosin was genetically fused to a nanobody of a green fluorescent protein (GFP). A recombinant protein consisting of immunoglobulin-binding protein LG fused to GFP was used to couple the oleosome to an antibody for targeted delivery to breast cancer cells. The lipid core of the oleosome was loaded with magnetic nanoparticles and carmustine as the lipophilic drug. The magnetic oleosome was characterized using transmission electron microscopy and dynamic light scattering. Moreover, the specific delivery of oleosome into the target cancer cell was investigated via confocal microscopy. To examine the cell viability of the delivered oleosome, a conventional 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was carried out. Furthermore, an animal study was conducted to confirm the effect resulting from the delivery of the anticancer drug-loaded oleosomes. Taken together, the fabricated lipophilic drug-loaded magnetic...Continue Reading

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Citations

Apr 27, 2018·Biotechnology Journal·Kyeong-Jun KimJeong-Woo Choi
Jan 9, 2019·Frontiers in Chemistry·Paige M PriceLyudmila M Bronstein
Dec 31, 2019·Environmental Science and Pollution Research International·Jobin JoseBijo Mathew
Jul 14, 2019·Seminars in Cancer Biology·Balney RajithaGanji Purnachandra Nagaraju
Apr 9, 2021·Progress in Lipid Research·Alexsandra Conceição ApolinárioLuciana Biagini Lopes

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