Magnetic particle imaging for in vivo blood flow velocity measurements in mice

Physics in Medicine and Biology
M G KaulCaroline Jung

Abstract

Magnetic particle imaging (MPI) is a new imaging technology. It is a potential candidate to be used for angiographic purposes, to study perfusion and cell migration. The aim of this work was to measure velocities of the flowing blood in the inferior vena cava of mice, using MPI, and to evaluate it in comparison with magnetic resonance imaging (MRI). A phantom mimicking the flow within the inferior vena cava with velocities of up to 21 cm s-1 was used for the evaluation of the applied analysis techniques. Time-density and distance-density analyses for bolus tracking were performed to calculate flow velocities. These findings were compared with the calibrated velocities set by a flow pump, and it can be concluded that velocities of up to 21 cm s-1 can be measured by MPI. A time-density analysis using an arrival time estimation algorithm showed the best agreement with the preset velocities. In vivo measurements were performed in healthy FVB mice (n  =  10). MRI experiments were performed using phase contrast (PC) for velocity mapping. For MPI measurements, a standardized injection of a superparamagnetic iron oxide tracer was applied. In vivo MPI data were evaluated by a time-density analysis and compared to PC MRI. A Bland-Altman ...Continue Reading

References

Sep 1, 1978·The American Journal of Physiology·K M BaldwinR E Lewis
Jul 1, 1995·Journal of Magnetic Resonance Imaging : JMRI·R FrayneB K Rutt
Jun 28, 2000·Physics in Medicine and Biology·J M BoeseL R Schad
Dec 18, 2001·Journal of Magnetic Resonance Imaging : JMRI·Y PapaharilaouS J Sherwin
Apr 6, 2004·Journal of Magnetic Resonance Imaging : JMRI·Shawn WagnerWolfgang Schaper
Apr 13, 2005·IEEE Transactions on Medical Imaging·Kawal S RhodeAlexander M Seifalian
Jul 1, 2005·Nature·Bernhard Gleich, Jürgen Weizenecker
Aug 12, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sylvain MirauxEric Thiaudière
Mar 10, 2007·Ultrasound in Medicine & Biology·Craig J HartleyGeorge E Taffet
Jan 30, 2009·JAMA : the Journal of the American Medical Association·Rosemarie MetMark J W Koelemay
Feb 11, 2009·Physics in Medicine and Biology·J WeizeneckerJ Borgert
Aug 18, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Smbat AmirbekianJohn N Oshinski
Jul 10, 2012·Circulation Research·Thibaut Quillard, Peter Libby
Nov 3, 2012·JAMA : the Journal of the American Medical Association·Mike Mitka
May 13, 2015·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·M G KaulG Adam

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Citations

Sep 7, 2019·Nanotechnology·Kai WuJian-Ping Wang
Jun 17, 2020·Nature Biomedical Engineering·Kyung Oh JungGuillem Pratx
Oct 4, 2019·Innovative Surgical Sciences·Anna C BakeneckerKerstin Lüdtke-Buzug
Mar 3, 2021·Scientific Reports·Michael Gerhard KaulKersten Peldschus
May 29, 2021·Chemical Society Reviews·Chang LuJianghong Rao
Apr 16, 2021·Annual Review of Chemical and Biomolecular Engineering·Angelie Rivera-Rodriguez, Carlos M Rinaldi-Ramos
Aug 18, 2021·International Journal of Radiation Biology·Tong YuanSaijun Fan
Oct 8, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Peter LudewigTobias Knopp

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