Abstract
The dinuclear complex bis[(μ(2)-chloro)chloro(1,10-phenanthroline)copper(II)] (1) was synthesized, and characterized by X-ray, FTIR and thermal analysis. The fitting of magnetic susceptibility and magnetization curve of (1) indicates the occurrence of weak antiferromagnetic exchange interaction between copper(II) ions. The electronic structure has been also determined by density functional theory (DFT) method. Complex (1) displayed potent anticancer activity against B16 (Melanoma), MDA-MB-32 (Breast Adenocarcinoma), A549 (Lung Adenocarcinoma), HT-29 (Colon Adenocarcinoma) and SF (Astrocytoma) cell lines with an average IC50 value of 0.726 μg/ml compared to 4.88 μg/ml for cisplatin. Complex (1) has a better therapeutic index and toxicological profile than cisplatin, and has demonstrated a potential chemotherapeutic property.
References
May 18, 2000·Cancer Treatment Reviews·M M EatockS B Kaye
Sep 7, 2000·Journal of Clinical Pharmacology·J P DutcherP H Wiernik
Mar 22, 2002·The Lancet Oncology·S B FoxA L Harris
Aug 28, 2003·Current Opinion in Chemical Biology·Christiana Xin Zhang, Stephen J Lippard
Dec 4, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroK D Tew
Mar 25, 2005·Nature Reviews. Drug Discovery·Dong Wang, Stephen J Lippard
Apr 6, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Li Hong ShenMichael Chopp
Dec 1, 2007·Science·Trevor W Hambley
Feb 5, 2008·Journal of Inorganic Biochemistry·Eleni K EfthimiadouGeorge Psomas
May 3, 2008·Chemico-biological Interactions·Hassan H HammudJulnar Usta
May 14, 2008·Metal-based Drugs·I Gracia-MoraM E Bravo-Gómez
May 29, 2008·Clinical and Experimental Pharmacology & Physiology·Lydia FinneyDavid Glesne
Feb 10, 2009·Anti-cancer Agents in Medicinal Chemistry·Cristina MarzanoCarlo Santini
Jun 30, 2009·The Journal of Biological Chemistry·Saverio TarditoRenata Franchi-Gazzola
Aug 6, 2010·Chemical & Pharmaceutical Bulletin·Lei JiaNing Tang
Dec 18, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Andrew KellettMichael Devereux
Apr 19, 2011·Journal of Inorganic Biochemistry·Z BoulsouraniC Dendrinou-Samara
May 7, 2011·European Journal of Medicinal Chemistry·Jagadeesan LakshmiprabaThyagarajan Thirunalasundari
May 24, 2011·European Journal of Medicinal Chemistry·P KrishnamoorthyN Dharmaraj
Oct 11, 2011·Cancer Chemotherapy and Pharmacology·Caroline HaglundElin Lindhagen
Oct 12, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Zhen ZhangQ Ping Dou
Oct 10, 2013·Chemical Reviews·Carlo SantiniCristina Marzano
Citations
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Arpad Mihai RostasRodica Olar
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nidia D Corona-MotoliniaEnrique González-Vergara
Aug 6, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Rodica OlarMariana Carmen Chifiriuc
Sep 23, 2021··M. SeenivasanS. Priyanka