Magnetic Propulsion of Microswimmers with DNA-Based Flagellar Bundles

Nano Letters
Alexander M MaierTim Liedl

Abstract

We show that DNA-based self-assembly can serve as a general and flexible tool to construct artificial flagella of several micrometers in length and only tens of nanometers in diameter. By attaching the DNA flagella to biocompatible magnetic microparticles, we provide a proof of concept demonstration of hybrid structures that, when rotated in an external magnetic field, propel by means of a flagellar bundle, similar to self-propelling peritrichous bacteria. Our theoretical analysis predicts that flagellar bundles that possess a length-dependent bending stiffness should exhibit a superior swimming speed compared to swimmers with a single appendage. The DNA self-assembly method permits the realization of these improved flagellar bundles in good agreement with our quantitative model. DNA flagella with well-controlled shape could fundamentally increase the functionality of fully biocompatible nanorobots and extend the scope and complexity of active materials.

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Citations

Jul 20, 2016·Nano Letters·Pietro TiernoJosé M Sancho
Feb 12, 2017·ACS Nano·Yingfeng TuDaniela A Wilson
Jan 27, 2017·ACS Nano·Alexander Mario MaierTim Liedl
Mar 10, 2017·Scientific Reports·Joshua K HamiltonFeodor Y Ogrin
May 10, 2017·Lab on a Chip·Hakan CeylanMetin Sitti
Nov 23, 2016·Nature Communications·Francisca Guzmán-LastraHartmut Löwen
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Jun 28, 2019·Soft Matter·Parvin BayatiAli Najafi
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Jun 27, 2020·ACS Synthetic Biology·Sami NummelinVeikko Linko
Aug 20, 2020·ACS Applied Materials & Interfaces·Gong ChengSi-Yang Zheng

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Methods Mentioned

BETA
Fluorescence microscopy

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