Magnetic resonance contrast agents in optical clearing: Prospects for multimodal tissue imaging.

Journal of Biophotonics
Daria K TuchinaValery V Tuchin

Abstract

Skin optical clearing effect ex vivo and in vivo was achieved by topical application of low molecular weight paramagnetic magnetic resonance contrast agents. This novel feature has not been explored before. By using collimated transmittance the diffusion coefficients of three clinically used magnetic resonance contrast agents, that is Gadovist, Magnevist and Dotarem as well as X-ray contrast agent Visipaque in mouse skin were determined ex vivo as (4.29 ± 0.39) × 10-7 cm2 /s, (5.00 ± 0.72) × 10-7 cm2 /s, (3.72 ± 0.67) × 10-7 cm2 /s and (1.64 ± 0.18) × 10-7 cm2 /s, respectively. The application of gadobutrol (Gadovist) resulted in efficient optical clearing that in general, was superior to other contrast agents tested and allowed to achieve: (a) more than 12-fold increase of transmittance over 10 minutes after application ex vivo; (b) markedly improved images of skin architecture obtained with optical coherence tomography; (c) an increase of the fluorescence intensity/background ratio in TagRFP-red fluorescent marker protein expressing tumor by five times after 15 minutes application into the skin in vivo. The obtained results have immediate implications for multimodality imaging because many contrast agents are capable of simul...Continue Reading

References

Mar 9, 2004·Lasers in Surgery and Medicine·Misbah H KhanJ Stuart Nelson
Dec 29, 2006·Contrast Media & Molecular Imaging·Sophie LaurentRobert N Muller
Apr 26, 2007·Journal of Magnetic Resonance Imaging : JMRI·Shao-Pow Lin, Jeffrey J Brown
Nov 6, 2010·Expert Review of Medical Devices·Elina A GeninaValery V Tuchin
Feb 2, 2011·Journal of Biomedical Optics·Katherine CalabroIrving J Bigio
Oct 1, 1997·Journal of Biomedical Optics·V V TuchinA A Mishin
Oct 13, 2012·Nature Protocols·Ali ErtürkHans-Ulrich Dodt
Dec 19, 2013·Laser & Photonics Reviews·Dan ZhuValery V Tuchin
Jan 15, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Valérie C PierrePeter Caravan
Jan 29, 2014·Contrast Media & Molecular Imaging·Gisela E HagbergNikos K Logothetis
Mar 12, 2015·Journal of Biophotonics·Daria K TuchinaValery V Tuchin
Jul 18, 2015·Cell·Douglas S Richardson, Jeff W Lichtman
Jul 23, 2015·Biophysical Journal·Karen S SarkisyanAlexander S Mishin
Jun 22, 2016·Scientific Reports·Ayelet Akselrod-BallinMichal Neeman
Aug 23, 2016·Nature Methods·Chenchen PanAli Ertürk
Jan 31, 2017·Journal of Biophotonics·Anton SdobnovValery Tuchin
Aug 3, 2017·Journal of Biophotonics·Luís M OliveiraValery V Tuchin
Jan 18, 2018·Methods in Molecular Biology·Daniel CalleSebastián Cerdán
May 15, 2018·Frontiers of Physics·Ileana O Jelescu, Matthew D Budde
Jul 15, 2018·Clinical Drug Investigation·Lesley J Scott
Jul 26, 2018·Journal of Biophotonics·Yulia M AlexandrovskayaEmil N Sobol
Aug 23, 2018·Cell Reports·Kazuki TainakaHiroki R Ueda
Aug 25, 2018·Journal of Biomedical Optics·Alexey N BashkatovValery V Tuchin
Aug 30, 2018·Neurophotonics·Peng WanDan Zhu
Feb 13, 2019·Science Advances·Yisong QiDan Zhu
Mar 20, 2019·Biomedical Engineering Online·Michael Meyer
Jul 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mikhail InyushinAstrid Zayas-Santiago
Oct 28, 2019·Biomedical Optics Express·Irene CostantiniFrancesco Saverio Pavone
Nov 2, 2019·Quantitative Imaging in Medicine and Surgery·Zelong ChenGuanshu Liu
Nov 22, 2019·Nature Protocols·Katsuhiko MatsumotoHiroki R Ueda

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Citations

Sep 3, 2021·Chaos·Nadezhda Semenova, Valery V Tuchin

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