Magnetic resonance elastography in nonlinear viscoelastic materials under load

Biomechanics and Modeling in Mechanobiology
Adela CapilnasiuDavid Nordsletten

Abstract

Characterisation of soft tissue mechanical properties is a topic of increasing interest in translational and clinical research. Magnetic resonance elastography (MRE) has been used in this context to assess the mechanical properties of tissues in vivo noninvasively. Typically, these analyses rely on linear viscoelastic wave equations to assess material properties from measured wave dynamics. However, deformations that occur in some tissues (e.g. liver during respiration, heart during the cardiac cycle, or external compression during a breast exam) can yield loading bias, complicating the interpretation of tissue stiffness from MRE measurements. In this paper, it is shown how combined knowledge of a material's rheology and loading state can be used to eliminate loading bias and enable interpretation of intrinsic (unloaded) stiffness properties. Equations are derived utilising perturbation theory and Cauchy's equations of motion to demonstrate the impact of loading state on periodic steady-state wave behaviour in nonlinear viscoelastic materials. These equations demonstrate how loading bias yields apparent material stiffening, softening and anisotropy. MRE sensitivity to deformation is demonstrated in an experimental phantom, show...Continue Reading

References

Sep 1, 1996·Biomaterials·K S AnsethL Brannon-Peppas
Jun 28, 2000·Physics in Medicine and Biology·R SinkusD Holz
Dec 4, 2001·Medical Image Analysis·A ManducaR L Ehman
Jun 7, 2002·Ultrasound in Medicine & Biology·Wen-Chun YehPo-Huang Lee
Dec 25, 2002·Journal of Magnetic Resonance Imaging : JMRI·Elijah E W Van HoutenKeith D Paulsen
Oct 29, 2004·Physics in Medicine and Biology·Miklos Z KissTimothy J Hall
Jan 29, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R SinkusM Fink
Feb 24, 2005·Physics in Medicine and Biology·K J M SurryT M Peters
Apr 19, 2005·Magnetic Resonance Imaging·Ralph SinkusMathias Fink
Mar 8, 2006·NMR in Biomedicine·Laurent HuwartBernard E Van Beers
Jul 20, 2006·Journal of the Royal Society, Interface·T Christian GasserGerhard A Holzapfel
Aug 17, 2006·Biomechanics and Modeling in Mechanobiology·I HaritonG A Holzapfel
Oct 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ralph SinkusMathias Fink
Feb 6, 2008·The Journal of the Acoustical Society of America·J-L GennissonM Fink
May 7, 2008·NMR in Biomedicine·Michael A GreenRalph Sinkus
May 13, 2008·Gastroenterology·Laurent HuwartBernard E Van Beers
Oct 17, 2008·Investigative Radiology·Thomas ElgetiIngolf Sack
Apr 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Arunark KolipakaRichard L Ehman
Jul 25, 2009·Journal of the Mechanical Behavior of Biomedical Materials·V PazosJ C Tardif
Aug 7, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Gerhard A Holzapfel, Ray W Ogden
Aug 12, 2009·Medical Image Analysis·Vicky Y WangMartyn P Nash
Sep 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Benjamin RobertMathias Fink
Oct 7, 2009·Annals of Biomedical Engineering·Zhan GaoJaydev P Desai
Nov 18, 2009·Progress in Biophysics and Molecular Biology·D A NordslettenN P Smith
Dec 4, 2009·Journal of Biomechanics·S NicolleJ-F Palierne
Dec 17, 2009·Topics in Magnetic Resonance Imaging : TMRI·Meng YinRichard L Ehman
Jun 15, 2010·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Yogesh K MariappanRichard L Ehman
Jun 26, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Arunark KolipakaRichard L Ehman
Aug 5, 2010·Cleveland Clinic Journal of Medicine·Emily Carey, William D Carey
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Vijay RajagopalMartyn P Nash
Sep 21, 2010·IEEE Transactions on Medical Imaging·Mathieu CouadeMickael Tanter
Apr 19, 2011·Ultrasound in Medicine & Biology·Deirdre M KingJacinta E Browne
Aug 3, 2011·Journal of Biomedical Optics·Wenfeng XiaSrirang Manohar
Jan 17, 2012·NMR in Biomedicine·M A GreenL E Bilston
Feb 16, 2012·Journal of Magnetic Resonance Imaging : JMRI·Arunark KolipakaPhilip A Araoz
Apr 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Katharina SchregelRalph Sinkus
Jun 6, 2012·IEEE Transactions on Medical Imaging·Sevan GoenezenAssad A Oberai
Sep 19, 2012·Journal of Magnetic Resonance Imaging : JMRI·Kevin J GlaserRichard L Ehman
Sep 19, 2012·Journal of Magnetic Resonance Imaging : JMRI·Eric C QinLynne E Bilston
May 4, 2013·NMR in Biomedicine·M A GreenL E Bilston
Apr 29, 2014·Computers in Biology and Medicine·Matthew McCormickNicolas P Smith

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BETA
rheology
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