Magnetic Resonance Enterography (MRE) Healing and MRE Remission Predicts Improved Outcome in Pediatric Crohn Disease

Journal of Pediatric Gastroenterology and Nutrition
Cary G SauerSubra Kugathasan

Abstract

Mucosal healing predicts clinical remission and improved outcomes in patients with Crohn Disease (CD). Magnetic resonance enterography (MRE) is a noninvasive imaging modality that can assess small and large bowel wall inflammation. Evidence suggests that MRE may be an acceptable alternative to evaluate mucosal healing over endoscopy. Our objective is to determine if MRE remission predicts clinical remission at follow-up in children with CD. We performed a IRB-approved retrospecitve chart review using our prospectively-maintained MRE CD database. Inclusion criteria were all children who underwent an MRE more than 6 months after diagnosis with CD who had follow up of at least one year from imaging. 101 children with CD underwent MRE a median of 1.3 years from diagnosis with a median follow-up of 2.8 years. Active inflammation was detected in 65 MRE studies while 36 MRE studies demonstrated MRE remission. 88.9% of children demonstrating MRE remission were in clinical remission at follow up while only 44.6% of those demonstrating MRE active inflammation achieved clinical remission. Children demonstrating MRE active inflammation were more likely to have a change in medication (44.6% vs. 8.3%) and more likely to undergo surgery (18.5...Continue Reading

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Citations

Feb 13, 2016·Current Treatment Options in Gastroenterology·Peter Bossuyt, Séverine Vermeire
Jun 29, 2016·AJR. American Journal of Roentgenology·Matthew P MoyMichael S Gee
Jun 21, 2016·Expert Review of Clinical Immunology·Kaija-Leena Kolho, Antti Ainamo
Apr 1, 2017·Journal of Pediatric Gastroenterology and Nutrition·Klara FrivoltSibylle Koletzko
Apr 22, 2020·Expert Review of Gastroenterology & Hepatology·Salvatore CucchiaraLaura Stronati
Jun 10, 2020·Expert Review of Gastroenterology & Hepatology·Eirini ZacharopoulouMariangela Allocca
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Jun 24, 2020·Paediatric Drugs·Giulia D'Arcangelo, Marina Aloi
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Jun 7, 2021·The Lancet. Gastroenterology & Hepatology·Sophie GeylLaurent Peyrin-Biroulet
Jun 24, 2021·Digestive Diseases and Sciences·Aurélie GrandmouginValérie Laurent

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Methods Mentioned

BETA
imaging techniques
sedation

Software Mentioned

SAS

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