Magnetic Resonance Guided Navigation of Untethered Microgrippers.

Advanced Healthcare Materials
Arijit GhoshDavid H Gracias

Abstract

Microsurgical tools offer a path to less invasive clinical procedures with improved access, reduced trauma, and better recovery outcomes. There are a variety of rigid and flexible endoscopic devices that have significantly advanced diagnostics and microsurgery. However, they rely on wires or tethers for guidance and operation of small end-effector tools. While untethered physiologically responsive microgrippers have been previously shown to excise tissue from deep gastrointestinal locations in animal models, there are challenges associated with guiding them along paths and moving them to specific locations. In this communication, the magnetic dipole moment of untethered thermally responsive grippers is optimized for efficient coupling to external magnetic resonance (MR) fields. Gripper encapsulation in a millimeter sized wax pellet reduces the friction with the surrounding tissue and MR Navigation (MRN) of a 700 µm sized microgripper is realized within narrow channels in tissue phantoms and in an ex vivo porcine esophagus. The results show convincing proof-of-concept evidence that it is possible to sequentially image, move, and guide a submillimeter functional microsurgical tool in tissue conduits using a commercial preclinical...Continue Reading

References

Oct 14, 2004·Journal of the American Chemical Society·Walter F PaxtonVincent H Crespi
Dec 5, 2008·Journal of the American Chemical Society·Jatinder S RandhawaDavid H Gracias
Jan 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Timothy G LeongDavid H Gracias
May 6, 2009·Nano Letters·Ambarish Ghosh, Peer Fischer
Mar 11, 2010·Advanced Materials·Jatinder S RandhawaDavid H Gracias
Apr 27, 2010·Annual Review of Biomedical Engineering·Bradley J NelsonJake J Abbott
May 3, 2011·Annual Review of Biomedical Engineering·Panagiotis VartholomeosConstantinos Mavroidis
May 20, 2011·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Pavel S YarmolenkoMark W Dewhirst
May 29, 2012·ACS Nano·Wei WangThomas E Mallouk
Oct 11, 2012·Advanced Materials·Evin GultepeDavid H Gracias
Feb 13, 2013·Gastroenterology·Evin GultepeFlorin M Selaru
Jul 1, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elizabeth NanceRichard J Price
Jun 17, 2015·Nano Letters·Jinxing LiJoseph Wang
Aug 3, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Raag D AiranMartin G Pomper
Feb 1, 2015·Proceedings of the IEEE·Metin SittiEric Diller
Aug 18, 2017·Nature Communications·Berta Esteban-Fernández de ÁvilaJoseph Wang
Aug 24, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Curtis N WiensScott B Reeder
Sep 28, 2017·Chemical Society Reviews·Leilei XuJianguo Guan
Nov 9, 2018·Science Advances·Zhiguang WuPeer Fischer
Jan 1, 2018·IEEE Transactions on Automation Science and Engineering : a Publication of the IEEE Robotics and Automation Society·C PacchierottiS Misra
Jul 1, 2017·Frontiers in Mechanical Engineering·Arijit GhoshDavid H Gracias
Feb 14, 2020·Advanced Materials·Metin Sitti, Diederik S Wiersma
Apr 30, 2020·Nano Today·Arijit GhoshDavid H Gracias

❮ Previous
Next ❯

Citations

Jan 21, 2021·Chemical Society Reviews·Jinhua Li, Martin Pumera
Nov 12, 2020·Advanced Science·Fernando SotoUtkan Demirci

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

IEEE International Conference on Control and Automation : [proceedings]
Andrew ChoiDavid H Gracias
© 2021 Meta ULC. All rights reserved