Magnetic Resonance-guided Stereotactic Radiotherapy for Localized Prostate Cancer: Final Results on Patient-reported Outcomes of a Prospective Phase 2 Study.

European Urology Oncology
Shyama U TetarF J Lagerwaard

Abstract

The recent introduction of magnetic resonance-guided radiation therapy (MRgRT) has allowed improved treatment planning and delivery of stereotactic body radiotherapy (SBRT) in prostate cancer (PC). The health-related quality of life (HRQoL) outcomes using this novel approach are important in shared decision making for patients. To report HRQoL using both patient- and clinician-reported outcomes at 1 yr following stereotactic MRgRT for patients with localized PC. A prospective phase 2 trial included 101 patients with localized PC. All patients received 36.25Gy in five fractions of MRgRT delivered within 2 wk. HRQoL was prospectively assessed at baseline, at the last fraction, at 6 wk, and at 3, 6, 9, and 12 mo after treatment, by patient-reported outcome measures using European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-PR25 questionnaires, and International Prostate Symptom Score. At the same time points, clinicians reported on symptomatic adverse events (AEs). Effect sizes for changes in HRQoL were calculated with repeated measures analysis of variance. Availability of HRQoL data exceeded 95% at all study time points. From both questionnaires and the recorded AEs, the largest treatment effects on urinary...Continue Reading

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Citations

Dec 29, 2020·Frontiers in Oncology·Boris R ToccoAlison C Tree
Oct 16, 2020·Der Radiologe·Stefan A Koerber, Bettina Beuthien-Baumann
Feb 6, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Omar BohoudiFrank J Lagerwaard
Feb 20, 2021·Frontiers in Oncology·Juliane Hörner-RieberMarcel Verheij
Apr 20, 2021·Frontiers in Oncology·Luca BoldriniLaura Dawson
Aug 4, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hanbo ChenSuresh Senan
Sep 10, 2021·Urologia·Francesco CelliniVincenzo Valentini
Nov 19, 2021·CA: a Cancer Journal for Clinicians·William A HallClifton D Fuller

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