Magnetic resonance imaging and magnetic resonance cholangiopancreatography findings compared with fecal elastase 1 measurement for the diagnosis of chronic pancreatitis

Pancreas
Mehmet BilginWigbert S Rau

Abstract

To correlate magnetic resonance cholangiopancreatography (MRCP) and magnetic resonance imaging (MRI) findings of the pancreas with the pancreatic exocrine function determined by fecal elastase 1 concentration. Magnetic resonance imaging and MRCP findings of 81 consecutive patients with clinically suspected chronic pancreatitis and 21 healthy volunteers were evaluated. All subjects underwent MRI/MRCP and fecal elastase 1 testing within 1 to 4 weeks' interval. Magnetic resonance cholangiopancreatography images were evaluated according to Cambridge classification. Magnetic resonance imaging of the pancreas was assessed for pancreatic size, signal, and arterial enhancement. All volunteers had normal fecal elastase 1 levels (>200 microg/g) and normal MRI/MRCP findings. Thirty-one of 56 patients revealed MRI and/or MRCP findings despite normal fecal elastase 1 concentration. Four of 25 patients revealed normal MRI and MRCP findings despite low fecal elastase 1 concentration (<200 microg/g). Magnetic resonance imaging findings of size (P = 0.00001), arterial enhancement (P = 0.00001), and parenchymal signal (P = 0.001) were significantly different among the control group, patients with normal fecal elastase 1 levels, and patients with...Continue Reading

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Citations

Apr 29, 2010·Current Gastroenterology Reports·Nabil Elia ChoueiriFrank R Burton
Jun 20, 2008·AJR. American Journal of Roentgenology·Mehmet BilginWigbert S Rau
Nov 22, 2013·World Journal of Gastroenterology : WJG·Björn Lindkvist
Mar 13, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Michael LubarskyDiego R Martin
Jun 2, 2011·Nature Reviews. Gastroenterology & Hepatology·John S LeedsDavid S Sanders
Aug 19, 2009·Topics in Magnetic Resonance Imaging : TMRI·Numan Cem BalciFrank R Burton
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May 22, 2016·Abdominal Radiology·Nima Hafezi-NejadAtif Zaheer
Jan 6, 2009·Current Opinion in Gastroenterology·Darwin L Conwell, Peter A Banks
Mar 21, 2017·Digestive Diseases and Sciences·J Enrique Domínguez-MuñozMatthias J Löhr
Jan 12, 2019·Canadian Journal of Gastroenterology & Hepatology·Sinan AkayBelkıs Ünsal
Jun 19, 2021·BMJ Open Gastroenterology·Mary E PhillipsRajesh Kumar

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