Magnetic resonance imaging assessment of effective ablated volume following high intensity focused ultrasound

PloS One
Brett Z FiteKatherine W Ferrara

Abstract

Under magnetic resonance (MR) guidance, high intensity focused ultrasound (HIFU) is capable of precise and accurate delivery of thermal dose to tissues. Given the excellent soft tissue imaging capabilities of MRI, but the lack of data on the correlation of MRI findings to histology following HIFU, we sought to examine tumor response to HIFU ablation to determine whether there was a correlation between histological findings and common MR imaging protocols in the assessment of the extent of thermal damage. Female FVB mice (n = 34), bearing bilateral neu deletion tumors, were unilaterally insonated under MR guidance, with the contralateral tumor as a control. Between one and five spots (focal size 0.5 × 0.5 × 2.5 mm3) were insonated per tumor with each spot receiving approximately 74.2 J of acoustic energy over a period of 7 seconds. Animals were then imaged on a 7T MR scanner with several protocols. T1 weighted images (with and without gadolinium contrast) were collected in addition to a series of T2 weighted and diffusion weighted images (for later reconstruction into T2 and apparent diffusion coefficient maps), immediately following ablation and at 6, 24, and 48 hours post treatment. Animals were sacrificed at each time point a...Continue Reading

References

Feb 1, 1991·International Journal of Radiation Biology·B V HarmonG C Gobé
Jan 1, 1993·Ultrasound in Medicine & Biology·K HynynenJ F Schenck
Jan 1, 1993·European Urology·K HynynenJ F Schenck
May 23, 1998·The Journal of Biological Chemistry·R U JänickeA G Porter
Oct 24, 2000·Journal of Magnetic Resonance Imaging : JMRI·B QuessonC T Moonen
Dec 26, 2001·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·J D LeeW S Mun
Apr 12, 2002·Journal of Magnetic Resonance Imaging : JMRI·John D HazleR Jason Stafford
Apr 18, 2002·AJR. American Journal of Roentgenology·John R LeyendeckerFrancis E Sharkey
May 15, 2003·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M W DewhirstP J Hoopes
Sep 23, 2003·The British Journal of Radiology·J E KennedyD Cranston
Apr 22, 2004·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Tomy VargheseFred T Lee
Oct 14, 2005·Journal of Vascular and Interventional Radiology : JVIR·Muneeb AhmedS Nahum Goldberg
Apr 29, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Toyoaki UchidaTakefumi Satoh
Aug 8, 2007·IEEE Transactions on Medical Imaging·Viola RiekeKim Butts Pauly
Jan 26, 2008·Journal of Magnetic Resonance Imaging : JMRI·Viola Rieke, Kim Butts Pauly
Jul 23, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benjamin L VigliantiMark W Dewhirst
Sep 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·William A GrissomKim Butts-Pauly
Dec 2, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Andrew B HolbrookKim Butts Pauly
Mar 29, 2012·Cardiovascular and Interventional Radiology·Gina K HesleyDavid A Woodrum
Nov 19, 2013·Ultrasound in Medicine & Biology·Swetha SubramanianT Douglas Mast
Feb 25, 2014·Nature Reviews. Cancer·Katrina F Chu, Damian E Dupuy
Mar 19, 2014·Techniques in Vascular and Interventional Radiology·Marilyn A RoubidouxRoger Jason Stafford

❮ Previous
Next ❯

Citations

Nov 27, 2015·The British Journal of Radiology·Alberto BazzocchiUgo Albisinni
Apr 12, 2016·NMR in Biomedicine·Martijn HoogenboomArend Heerschap
Feb 12, 2017·Lab on a Chip·Yuta KurashinaJames Friend
Aug 10, 2016·Journal of Magnetic Resonance Imaging : JMRI·Damien BoudaMaxime Ronot
Dec 12, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Simona MorochnikMatthew D Bucknor
Aug 2, 2021·Advanced Drug Delivery Reviews·Nisi ZhangKatherine W Ferrara

❮ Previous
Next ❯

Software Mentioned

Thermoguide
Excel
MATLAB
ParaVision

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.