Magnetic resonance imaging-based prospective detection of intraperitoneal human ovarian carcinoma xenografts treatment response

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Jim KlostergaardRoger E Price

Abstract

The feasibility of applying magnetic resonance imaging (MRI) for conducting prospective studies of intraperitoneal (i.p.) tumor treatment response to chemotherapy and resultant effects on survival in human ovarian carcinoma/nude mouse orthotopic xenograft models was evaluated. Female nude mice were implanted i.p. with either NMP-1 or SKOV-3ip. human ovarian carcinoma cells on day 0. Initial T2-weighted magnetic resonance (MR) images of the abdomens of NMP-1-implanted mice were obtained on day 7 to confirm the presence of nascent tumors; similar confirmations were made on day 14 with mice bearing SKOV-3ip. xenografts. On the initial imaging days, a multiple-dose regimen of cisplatin (CDDP; qd7 x3) was commenced, using 4 or 6 mg/kg treatments with the NMP-1 model and using 6 mg/kg treatments with the SKOV-3ip. model. Mice were reimaged multiple times, 2 days following each CDDP injection and at later times as well, depending on host survival. The images for each mouse from the last imaging day (day 30 for NMP-1, day 44 for SKOV-3ip.) were used in a blinded fashion to attempt to visually distinguish control from treated mice and to determine whether MRI could predict a survival benefit. For SKOV-3ip. mice, ten out of ten mice were...Continue Reading

References

Apr 13, 1995·The New England Journal of Medicine·E K Rowinsky, R C Donehower
Jan 1, 1994·Pharmacotherapy·D R Kohler, B R Goldspiel
Sep 30, 1999·Bioconjugate Chemistry·Y Luo, G D Prestwich
Sep 23, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P PetignatR Obrist
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K. MujooN. J. Donato
Apr 12, 2001·Topics in Magnetic Resonance Imaging : TMRI·S M AscherR C Jha
May 18, 2001·British Journal of Cancer·M K TuxenP Dombernowsky
Sep 12, 2001·The Surgical Clinics of North America·F OdicinoS Pecorelli
Oct 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G J RustinT Meyer
Nov 17, 2001·Biomacromolecules·Y LuoG D Prestwich
Jan 12, 2002·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·E HovigK Nustad
May 4, 2002·Neoplasia : an International Journal for Oncology Research·Dominique JenningsRobert J Gillies
Jun 29, 2002·Scandinavian Journal of Clinical and Laboratory Investigation·M K TuxenP Dombernowsky
Jul 9, 2002·Obstetrics and Gynecology·Brian C CooperRichard E Buller
Jul 16, 2002·Radiologic Clinics of North America·Fergus V Coakley
Jan 22, 2004·Journal of the National Cancer Institute·Charles Bankhead

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Citations

Mar 17, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C L ZavaletaB A Goins
Jun 14, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sun Joo LeeAnil K Sood
Jul 3, 2007·Neoplasia : an International Journal for Oncology Research·Edmond AuzenneJim Klostergaard
Nov 10, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L ZhangA Wang
Dec 15, 2006·Gynecologic Oncology·Bohuslav MelicharRalph S Freedman
Feb 16, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hye Jeong LeeRonald R Price

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