Magnetic resonance imaging based radiomics signature for the preoperative discrimination of stage I-II and III-IV head and neck squamous cell carcinoma

European Journal of Radiology
Jiliang RenXiaofeng Tao

Abstract

This study aimed to investigate the predictive ability of magnetic resonance imaging (MRI) based radiomics signature for the preoperative staging in HNSCC. This study involved127 consecutive patients (training cohort: n = 85; testing cohort, n = 42) with stage I-IV HNSCC. A total of 970 radiomics features were extracted from T2-weighted (T2W) (n = 485) and contrast-enhanced T1-weighted (ceT1W) (n = 485) MRI for each case. Radiomics signatures were constructed with least absolute shrinkage and selection operator (LASSO) logistic regression. Associations between radiomics signatures and HNSCC staging were explored. Areas under the receiver operating characteristic curve (AUC) and classification performance of radiomics signatures were determined and compared with those of the visual assessment. Ten features from T2W images, six from ceT1W images, and six from combined T2W and ceT1W images were selected by LASSO logistic regression. The three radiomics signatures of stage III-IV HNSCC were significantly higher than that for stage I-II in both cohorts (all P < 0.05). The radiomics signatures from ceT1W and combined images performed well in the discrimination of stage I-II and III-IV HNSCC, with AUCs of 0.828 and 0.850 in the traini...Continue Reading

Citations

Jun 22, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Luca CozziMarta Scorsetti
Jul 17, 2020·Frontiers in Oncology·Heleen KoningsKristien J Ledeganck
Sep 16, 2020·AJR. American Journal of Roentgenology·Jiliang RenXiaofeng Tao
Jun 27, 2019·Current Oncology Reports·Stephanie NougaretEvis Sala
Jul 20, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Shuai MaXiaodong Zhang
Jun 5, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Stephanie Tanadini-LangMarta Bogowicz

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