Magnetic resonance imaging characteristics of nonthermal irreversible electroporation in vegetable tissue.

The Journal of Membrane Biology
Mohammad Hjouj, Boris Rubinsky

Abstract

We introduce and characterize the use of MRI for studying nonthermal irreversible electroporation (NTIRE) in a vegetative tissue model. NTIRE is a new minimally invasive surgical technique for tissue ablation in which microsecond, high electric-field pulses form nanoscale defects in the cell membrane that lead to cell death. Clinical NTIRE sequences were applied to a potato tuber tissue model. The potato is used for NTIRE studies because cell damage is readily visible with optical means through a natural oxidation process of released intracellular enzymes (polyphenol oxidase) and the formation of brown-black melanins. MRI sequences of the treated area were taken at various times before and after NTIRE and compared with photographic images. A comparison was made between T1W, T2W, FLAIR and STIR MRIs of NTIRE and photographic images. Some MRI sequences show changes in areas treated by irreversible electroporation. T1W and FLAIR produce brighter images of the treated areas. In contrast, the signal was lost from the treated area when a suppression technique, STIR, was used. There was similarity between optical photographic images of the treated tissue and MRIs of the same areas. This is the first study to characterize MRI of NTIRE ...Continue Reading

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Mar 2, 2010·Biomedical Engineering Online·Alex Golberg, Boris Rubinsky

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Citations

Mar 8, 2011·The Journal of Membrane Biology·Faisal MahmoodJulie Gehl
Aug 16, 2012·Cardiovascular and Interventional Radiology·J J WendlerU-B Liehr
Aug 15, 2013·Cardiovascular and Interventional Radiology·Robert E NealKenneth R Thomson
Jan 15, 2013·IEEE Transactions on Bio-medical Engineering·Alexander Golberg, Martin L Yarmush
Jun 10, 2015·IEEE Transactions on Bio-medical Engineering·Mohammad BonakdarRafael V Davalos
Sep 12, 2015·Biomedical Engineering Online·Suyashree P BhonsleRafael V Davalos
Jun 19, 2012·Physics of Life Reviews·Ana Leonor RiveraAchim M Loske
Dec 4, 2012·Biophysical Journal·Christopher B ArenaRafael V Davalos
Dec 2, 2014·PloS One·Cecilia SuárezGuillermo Marshall
Jan 10, 2012·British Journal of Cancer·M A PhillipsB Rubinsky
Apr 25, 2018·Cardiovascular and Interventional Radiology·Alette H RuarusMartijn R Meijerink
Jul 20, 2017·Annals of Biomedical Engineering·Tyler MiklovicMichael B Sano

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