PMID: 3752010Oct 1, 1986Paper

Magnetic resonance imaging compared with computed tomography in adrenoleukodystrophy

American Journal of Diseases of Children
M S HuckmanG K Geremia

Abstract

Adrenoleukodystrophy was diagnosed in two siblings and confirmed by analysis of very-long-chain fatty acids in skin fibroblasts. Both boys had computed tomograms (CTs) and magnetic resonance imaging (MRI) of the brain. In the most severely affected child, the CT and MRI examinations were both abnormal, but in the other child, the CT was mildly abnormal but the MRI was unequivocally abnormal. This suggests that MRI is more sensitive than CT in detecting the acute demyelinating changes of adrenoleukodystrophy and, in conjunction with very-long-chain fatty acid analysis, should be useful in screening unaffected or mildly affected siblings of patients with this disease.

Citations

Sep 1, 1989·Indian Journal of Pediatrics·R P SinghK Garg
Jan 1, 1991·Neuroradiology·M UchiyamaS Tada
Jan 11, 1991·Pediatric Radiology·H P Hatten
Jan 1, 1995·Pediatric Radiology·P J PatelM Saleh
Aug 1, 1996·Acta Paediatrica Japonica; Overseas Edition·N WadaT Sawada

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Adrenoleukodystrophy (ALD), the most frequent peroxisomal disorder, is an X-linked disorder caused by a defect in the metabolism of long chain fatty acids leading to demyelination, neurodegeneration, and death. Here is the latest research.