Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis: a pilot study

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Andy de Oliveira VicenteNorma O Penido

Abstract

To evaluate the applicability of magnetic resonance imaging (MRI) as a method for monitoring the activity of otospongiotic lesions before and after clinical treatment. Prospective, randomized, controlled, double-blind study. One single tertiary care institution in a large, cosmopolitan city. Twenty-six patients (n = 42 ears) with clinical, audiometric, and tomographic diagnosis of otosclerosis were enrolled. If computed tomography (CT) demonstrated active lesions, these patients underwent MRI to detect otospongiotic foci, seen as areas of gadolinium enhancement. Patients were divided into 3 groups and received treatment with placebo, sodium alendronate, or sodium fluoride for 6 months. After this period, clinical and audiometric evaluations and a second MRI were performed. Each MRI was evaluated by both a neuroradiologist and an otolaryngologist in a subjective (visual) and objective (using specific eFilm Workstation software) manner. Otospongiosis was most predominantly identified in the region anterior to the oval window, and this site was reliable for comparing pre- and posttreatment scans. The patients in the alendronate and sodium fluoride groups had MRI findings that suggested a decrease in activity of otospongiotic lesio...Continue Reading

References

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Mar 28, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Andy de Oliveira VicenteNorma de Oliveira Penido

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Citations

Feb 5, 2016·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Shinji NaganawaMitsuru Ikeda
Jan 10, 2016·European Radiology·Francesco LombardoRaffaello Canapicchi
Nov 15, 2018·British Journal of Sports Medicine·Alex KountourisJill L Cook
Jan 17, 2019·Journal of Hip Preservation Surgery·Peter J MoleyBryan T Kelly
May 6, 2019·Spine Deformity·A Noelle LarsonJean Dubousset
Sep 8, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Stefano BerrettiniFrancesca Forli
May 11, 2021·International Archives of Otorhinolaryngology·Lucas Resende Lucinda MangiaRogerio Hamerschmidt

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Methods Mentioned

BETA
PCR

Software Mentioned

eFilm Workstation
RAOW
Florical

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