Magnetic resonance imaging in the quantitative assessment of gouty tophi

International Journal of Clinical Practice
H R SchumacherN Joseph-Ridge

Abstract

Measurements of tophus size can be important in monitoring the course of gout therapy, as tophus resolution is proposed as one measure of success of treatment. This multicentre study assessed the intra- and interreader reproducibility of quantitative tophus volume measurements from magnetic resonance images (MRI) in subjects with palpable gouty tophi. Subjects first underwent radiographic imaging of a selected tophus followed by MRI before and at <or=5, 10 and 20-min after gadolinium administration. After choosing optimal parameters, subjects underwent pre- and postgadolinium-enhanced MRIs of a selected tophus on two occasions separated by 5-10 days. Unenhanced spin-echo images provided satisfactory tophi images and were less subject to interfering artefacts than gadolinium-enhanced gradient-echo images. Intrareader reproducibility was excellent, with no statistically significant difference in mean tophus volume between visits (mean difference - 0.05 +/- 0.97 cm3). A small but statistically significant difference in interreader mean tophus volume was detected (mean difference 0.89 +/- 2.05 cm3; p < 0.05). MRI can quantify tophus size in gout and deserves further comparison with other techniques for tophus size monitoring in ass...Continue Reading

Associated Clinical Trials

References

Jan 1, 1995·American Journal of Nephrology·D C TarngT P Huang
Feb 1, 1996·Seminars in Arthritis and Rheumatism·J D PoppN L Edwards
Feb 1, 1997·AJR. American Journal of Roentgenology·J S YuR Jurdi
Feb 1, 2000·Skeletal Radiology·D WeishauptK Wapner
Aug 23, 2000·AJR. American Journal of Roentgenology·C K ChenD Resnick
May 3, 2001·Current Opinion in Rheumatology·N Schlesinger, H R Schumacher
May 1, 2002·Current Opinion in Rheumatology·Robert L Wortmann
Jun 22, 2002·Seminars in Musculoskeletal Radiology·Amilcare GentiliSulabha Masih
Jun 28, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Holly Mattix Kramer, Gary Curhan
Sep 5, 2002·Arthritis and Rheumatism·Fernando Perez-RuizAna Ruibal

❮ Previous
Next ❯

Citations

Nov 19, 2013·International Journal of Rheumatic Diseases·Ying SunLindi Jiang
Jul 14, 2009·Arthritis Research & Therapy·Fernando Perez-RuizNaomi Schlesinger
Nov 17, 2011·Arthritis Research & Therapy·Fiona M McQueenNicola Dalbeth
Mar 24, 2010·AJR. American Journal of Roentgenology·Savvakis NicolaouPeter Munk
Mar 26, 2014·AJR. American Journal of Roentgenology·Shima AranHani H Abujudeh
Sep 16, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Madhura A DesaiMark J Kransdorf
Oct 7, 2015·Journal of Medical Imaging and Radiation Oncology·Nishanthinie ParathithasanWarren Perera
Apr 8, 2014·Rheumatic Diseases Clinics of North America·Fiona M McQueenNicola Dalbeth
Jan 1, 2013·Best Practice & Research. Clinical Rheumatology·Fiona M McQueen, Mikkel Ostergaard
Jan 1, 2013·Best Practice & Research. Clinical Rheumatology·Nicola Dalbeth, Anthony J Doyle
Nov 3, 2015·Seminars in Arthritis and Rheumatism·Laura DurcanNicola Dalbeth
Apr 30, 2016·International Journal of Rheumatic Diseases·Zohra AhmadV Sreenivas
Nov 1, 2012·AJR. American Journal of Roentgenology·Savvakis NicolaouPeter Munk
Oct 25, 2014·Therapeutic Advances in Musculoskeletal Disease·Priya Varghese ChowalloorHelen Isobel Keen
Sep 4, 2015·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Declan J CurranMark R Towler
Dec 23, 2017·Rheumatology·Nicola Dalbeth, Anthony J Doyle
Feb 3, 2015·The Journal of Rheumatology·Rebecca GraingerWilliam J Taylor
Oct 13, 2009·The Journal of Rheumatology·Rebecca GraingerH Ralph Schumacher
Feb 7, 2007·Current Opinion in Rheumatology·Fernando Perez-Ruiz, Esperanza Naredo
Mar 31, 2007·Arthritis and Rheumatism·Nicola DalbethFiona M McQueen
Mar 20, 2008·Current Opinion in Rheumatology·Rebecca Grainger, William J Taylor
Jul 28, 2010·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Kai-Hsiung KoGuo-Shu Huang
Jan 11, 2012·Nature Reviews. Rheumatology·Fiona M McQueenNicola Dalbeth
Apr 3, 2009·Current Opinion in Rheumatology·Nicola Dalbeth, Fiona M McQueen
Jun 4, 2020·Skeletal Radiology·William PalmerChristian W A Pfirrmann
Aug 13, 2014·Annals of the Rheumatic Diseases·Opetaia AatiNicola Dalbeth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.