Magnetic resonance imaging of cancer metabolism with hyperpolarized 13 C-labeled cell metabolites

Current Opinion in Chemical Biology
Richard Hesketh, Kevin Brindle

Abstract

Hyperpolarization of 13C-labeled substrates can increase their 13C NMR signal by more than 10000-fold, which has allowed magnetic resonance imaging (MRI) of metabolic reactions in vivo. This has already provided a unique insight into the dysregulated metabolic pathways and microenvironment of tumors. Perhaps the best known of the cancer-associated metabolic aberrations is the Warburg effect, which has been imaged in patients using hyperpolarized [1-13C]pyruvate. In clinical oncology there is a requirement to diagnose tumors earlier, better determine their aggressiveness and prognosis, identify novel treatment targets and detect response to treatment earlier. Here we consider some of the hyperpolarized substrates that have been developed and have the potential to meet these requirements and become the precision imaging tools of the future.

Citations

Mar 11, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Felix KreisKevin Brindle
Mar 26, 2020·International Journal of Cancer. Journal International Du Cancer·Yueqing GongJunjie Wang
Jan 27, 2019·Cancers·Alan CampbellRichard Hesketh
Dec 14, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lionel MignionBénédicte F Jordan
Jan 10, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Maria FalaKevin Brindle
Jan 15, 2021·Scientific Reports·Elisabeth BliemsriederRickmer Braren
Mar 10, 2020·Bioconjugate Chemistry·Dongjian ZhangJian Zhang
Mar 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Friederike HesseKevin Brindle
May 1, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Oleg G SalnikovEduard Y Chekmenev

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