Magnetic resonance imaging of changes in muscle tissues after membrane trauma

Annals of the New York Academy of Sciences
Hanne GisselRaphael C Lee

Abstract

A pure electroporation injury leads to cell membrane disruption and subsequent osmotic swelling of the tissue. The state of water in the injured area of a tissue is changed and differs from a healthy tissue. Magnetic resonance imaging (MRI), which is very sensitive to the quality of the interaction between mobile (water) protons and a restricted (protein) proton pool, is therefore a useful tool to characterize this injury. Here, we present a protocol designed to measure the difference between the values of the transverse magnetic relaxation time (T2) in MRIs of healthy and electrically injured tissue. In addition, we present a method to evaluate the two main contributions to the MRI contrast, the degree of structural alteration of the cellular components (including a major contribution from membrane pores), and edema. The approach is useful in assessing the level of damage that electric shocks produce in muscle tissues, in that edema will resolve in time whereas structural changes require active repair mechanisms.

References

Sep 1, 1978·Journal of Neuropathology and Experimental Neurology·S J PublicoverJ L Smith
Sep 1, 1991·Sports Medicine·R B ArmstrongJ A Warren
Jun 1, 1988·The Journal of Surgical Research·R C LeeD A Israel
Oct 1, 1984·European Journal of Clinical Investigation·M J JacksonR H Edwards
May 31, 1994·Annals of the New York Academy of Sciences·G S KarczmarM J Lipton
Nov 1, 1995·The Journal of Burn Care & Rehabilitation·T A BlockR C Lee
Mar 1, 1996·Burns : Journal of the International Society for Burn Injuries·H NettelbladF Sjöberg
Nov 20, 1997·Current Problems in Surgery·R C Lee
Aug 4, 1998·Burns : Journal of the International Society for Burn Injuries·M OhashiK Kikuchi
Mar 13, 1999·Nature Structural Biology·V P DenisovB Halle
Jun 21, 2001·Journal of Agricultural and Food Chemistry·H C BertramH J Andersen
Aug 31, 2001·Medicine and Science in Sports and Exercise·M R DeschenesW C Chandler
Mar 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hanne Gissel, Torben Clausen
Apr 9, 2005·Nature Reviews. Genetics·Khanh D Huynh, Jeannie T Lee

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