PMID: 8607092Apr 1, 1996Paper

Magnetic resonance imaging of human brain function

Surgical Neurology
M E MoseleyD M Spielman

Abstract

Previously the exclusive domain of the technology of positron emission tomography, functional MRI is now proving capable of mapping functional regions of the human cortex in near real time during specific task activations or in response to any hemodynamic stress. Of particular interest is the opportunity to observe secondary cortical responses, activation due to imagined tasks, memory function, time-resolved pathways through cortical regions, and activation in sub-cortical structures. One method of functional MRI uses blood oxygenation changes, which can be imaged continuously while functional centers are being stimulated. Image intensity can become darker if there is more deoxygenated blood and brighter if more oxygenated blood enters the brain. This concepts works in all perfused tissues in the body, and allows use of the blood oxygenation mechanism to image neuronal activation. A second method takes advantage of the fact that the protons within the MRI slice are always partially saturated by the rapid rate of imaging. As blood flow delivers unsaturated blood water protons into an imaged slice, these arterially-delivered protons will appear very bright in the image. Visualization of this effect is accomplished by simple image...Continue Reading

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K K KwongR Turner
Jun 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BandettiniJ S Hyde
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Citations

Sep 23, 2003·Brain Research. Brain Research Reviews·Georg Winterer, David Goldman
Jan 5, 2002·Neurologia Medico-chirurgica·Y HaraJ Kitamura
Jan 16, 2016·Der Radiologe·E R Gizewski
Dec 18, 2010·Neurología : publicación oficial de la Sociedad Española de Neurología·R Prieto-ArribasJ M Roda
Oct 27, 2006·Research in Veterinary Science·Elke R GizewskiThomas Laube
May 16, 2008·NeuroImage·Arijitt BorthakurChristopher M Clark

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