Magnetic resonance imaging of the brain and cerebral proton spectroscopy in patients with systemic lupus erythematosus

Arthritis and Rheumatism
R J ChinnM J Harrison

Abstract

To investigate the prevalence and extent of cerebral changes in patients with systemic lupus erythematosus (SLE) by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). SLE patients (47 women) and controls (25 women) underwent 1.5T MRI. A semiautomated segmentation technique calculated cerebrospinal fluid (CSF) and brain volumes. Proton MRS of the frontal and parieto-occipital white matter yielded metabolite ratios of N-acetyl groups (NA), choline, and creatine. Compared with the control group, the SLE patients more often had cerebral atrophy on MRI (32% versus 0%), confirmed by an increase in the CSF to intracranial volume ratio. The patients also had old infarcts and hemorrhages (8.5% versus 0%) and more small white matter lesions (23% versus 8% had > 5 such lesions). MRS showed relative reduction of NA peaks. Although no patient was studied when acutely ill, prior neurologic involvement was related to abnormal findings. MRI and MRS are helpful in the investigation of cerebral complications of SLE. There are chronic changes which may be ischemic in nature. Their precise cause, consequences, and prevention are current challenges.

References

Jun 9, 1979·Lancet·I LagensteinD Kühne
Jan 1, 1979·Journal of Neuroscience Research·R S Jope, D J Jenden
Jan 1, 1978·Journal of Computer Assisted Tomography·J BentsonG Wilson
Sep 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·O HenriksenP Arlien-Søborg
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·D L Birken, W H Oldendorf
Jul 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmR Sauter
Jul 30, 1987·The New England Journal of Medicine·E BonfaK B Elkon
Feb 1, 1986·Seminars in Arthritis and Rheumatism·D C AdelmanJ R Klinenberg
May 1, 1985·AJR. American Journal of Roentgenology·A M AisenW J McCune
Jun 25, 1984·Biochimica Et Biophysica Acta·S L Pelech, D E Vance
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
May 1, 1995·Developmental Medicine and Child Neurology·T HashimotoY Kuroda
Dec 1, 1994·Metabolic Brain Disease·S D Taylor-RobinsonD J Bryant
Mar 6, 1993·Lancet·I A Brosens
Feb 1, 1994·Brain : a Journal of Neurology·C A DavieW I McDonald
Jun 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R E BrennerW I McDonald
Apr 1, 1993·Seminars in Arthritis and Rheumatism·M M StimmlerF P Quismorio
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B J SoherP B Barker

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Citations

Feb 25, 1999·Journal of Magnetic Resonance Imaging : JMRI·H PetropoulosW M Brooks
Oct 19, 1999·Arthritis and Rheumatism·W L SibbittW M Brooks
Oct 16, 2012·Rheumatology International·Essam A AbdaSherifa A Hamed
Oct 6, 2007·Clinical Reviews in Allergy & Immunology·Bernardo Liberato, Roger A Levy
Dec 18, 2007·Clinical Reviews in Allergy & Immunology·Simone AppenzellerAnn E Clarke
Aug 1, 1997·Surgical Neurology·B B Kuzma, J M Goodman
Jul 20, 2002·Clinical Neurology and Neurosurgery·Vesna V Brinar
Jan 31, 2004·Journal of the International Neuropsychological Society : JINS·Janet L ShucardJulian Ambrus
Oct 18, 2001·Current Opinion in Rheumatology·T W HuizingaM A van Buchem
Mar 16, 2007·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Janet L ShucardDavid W Shucard
Apr 18, 2009·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Christopher M FilleyLening Zhang
Jan 25, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·M RovarisM Filippi
Jul 30, 2010·BMC Neurology·Rex E JungCarlos A Roldan
Apr 8, 2014·Autoimmunity Reviews·Enrico Maria ZardiAntonella Afeltra
Jul 3, 2013·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Elizabeth KozoraChristopher M Filley
Nov 26, 2009·Neurologic Clinics·Eyal Muscal, Robin L Brey
Feb 26, 2008·Autoimmunity Reviews·G CastellinoF Trotta
Jan 16, 2007·Brain Research Reviews·David A Ballok
Jan 16, 1999·Baillière's Clinical Rheumatology·J G Hanly
Mar 21, 2007·Magnetic Resonance Imaging·Lijuan ZhangAziz M Uluğ
Sep 13, 2008·Journal of Neurochemistry·Jessy John AlexanderAndrea Joan Tenner
Nov 1, 2008·Arthritis and Rheumatism·Elizabeth KozoraChristopher M Filley
Jan 15, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Sergio I Valdés-FerrerAntonio R Cabral
Sep 10, 2005·Best Practice & Research. Clinical Rheumatology·Pamela L PetersonDavid Isenberg
Apr 28, 2005·Clinical Imaging·Marcelo R AbreuFlávio Kapczinsky

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