PMID: 8585933Nov 1, 1995Paper

Magnetic resonance imaging of the galactosemic dog eye using magnetization transfer contrast

Current Eye Research
K MoriP F Kador

Abstract

Magnetization transfer contrast (MTC) enhanced magnetic resonance (MR) imaging is a technique that generates high contrast images based on characteristic tissue differences resulting from the interaction of water and macromolecules. In this study, the feasibility of applying this technique to documenting the progression of osmotic sugar cataract formation was investigated in male beagles, initially 6 or 24 month old, fed a diet containing 30% galactose. MTC enhanced magnetic resonance imaging was periodically conducted on these animal's eyes at 2-Tesla. The lens MR images were compared to photographs obtained by photo-slit lamp and retroillumination photography. The MTC technique provided improved image details of the lens and anterior segment that documented osmotic changes from initial cortical vacuole formation to cortical and nuclear changes associated with advanced sugar cataracts. The latter could not be observed by photo-slit lamp or retroillumination photography.

References

Jan 1, 1992·Experimental Eye Research·H M ChengC Chang
Jan 1, 1991·Magnetic Resonance Imaging·S LermanS P Souza
Jun 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R A Jones, T E Southon
Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J EngR S Balaban
Jan 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H M ChengM Mattingly
Mar 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T D ScholzR S Balaban

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Citations

May 20, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Peter F KadorT Terasaki
Apr 23, 2016·Progress in Retinal and Eye Research·Peter F KadorPeter J Oates
Jun 27, 2006·Experimental Eye Research·Carol B TorisPeter F Kador
Sep 23, 2003·The British Journal of Radiology·E De VitaR J Ordidge

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