PMID: 16623302Apr 21, 2006Paper

Magnetic resonance imaging of the prostate with spectroscopic imaging using a surface coil. Initial clinical experience

La Radiologia medica
G ManentiG Simonetti

Abstract

The purpose of this study was to evaluate the diagnostic ability of proton magnetic resonance spectroscopic imaging (MRSI) in the detection and localisation of prostate cancer, prospectively compared with histopathologic findings. Magnetic resonance imaging (MRI) and MRSI were performed on 39 patients with prostate-specific antigen (PSA) levels greater than 4 ng/ml and suspicious findings at trans-rectal ultrasound (TRUS). All patients underwent a TRUS ten-core biopsy within 30 days according to a subdivision of the prostate into octants. All studies were interpreted by a dedicated radiologist who reported the areas of interest as normal, equivocal or suspicious on MRI. At MRSI, cancer was defined as possible if the ratio of choline plus creatine to citrate exceeded mean normal peripheral zone values by two standard deviations (SD) or as definite if that ratio exceeded the normal value by three SD. MRI and MRSI findings were spatially correlated with findings obtained from individual biopsy sites. MRI and MRSI alone had sensitivity, specificity, positive and negative predictive values and diagnostic accuracy in the detection of prostate cancer equal to 85%, 75%; 53%, 89%; 65%, 88%; 77%, 74%; and 69%, 79%, respectively. These va...Continue Reading

Citations

Dec 20, 2007·Current Opinion in Urology·John KurhanewiczFergus Coakley
Jan 27, 2009·The British Journal of Radiology·A S N JacksonD P Dearnaley
Nov 6, 2012·Radiologic Clinics of North America·Saman Shafaat TalabShahin Tabatabaei
Sep 8, 2009·Urologic Oncology·Alessandro SciarraVincenzo Gentile
Feb 3, 2009·European Urology·Michael SeitzAnno Graser
Mar 23, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Virendra KumarRajeev Kumar
Dec 6, 2012·Journal of Medical Imaging and Radiation Oncology·Rocchina CaivanoAldo Cammarota
May 6, 2016·Technology in Cancer Research & Treatment·Huiyou ChenXindao Yin
Mar 5, 2011·Urologia Internationalis·Francesco PintoPierFrancesco Bassi
May 19, 2011·Nature Reviews. Urology·Elita M DeFeoLeo L Cheng
Apr 3, 2014·Iranian Red Crescent Medical Journal·Mahyar GhafooriMounes Aliyari Ghasabeh

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