PMID: 9525754Apr 3, 1998Paper

Magnetic resonance imaging relaxation times and gadolinium-DTPA relaxivity values in human cerebrospinal fluid

Investigative Radiology
M A IbrahimC W Cotman

Abstract

This study was conducted to prove the feasibility of using cerebrospinal fluid (CSF) T1 and T2 measurements to assess the blood-brain barrier integrity in disease states not noted for focal blood-brain barrier disruption, such as Alzheimer's disease. T1 and T2 of human CSF samples were measured with and without gadolinium Gd-DTPA over a concentration range of 1.98 x 10(-3) to 6.32 mM, in a GE 1.5-T Signa scanner. T1 and T2 of human CSF without Gd-DTPA were measured as 2.39 and 0.23 s. K1 and K2 were calculated as 6.25 and 6.74 mM(-1) s(-1). The lowest Gd-DTPA concentration with measurable T1 and T2 was 1.98 x 10(-3) mM. There is no statistically significant difference in T2 and K2 at different repetition times. This work demonstrates that a single measurement of relaxation times after contrast-enhanced magnetic resonance imaging could be used to determine the Gd-DTPA concentration in CSF. It may thus be feasible, using this technique, to measure intersubject and intraregional variability in the quantity of Gd-DTPA transferred across the blood-brain barrier after intravenous injection of contrast agent.

References

Jan 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·C A ChangK N Raymond
Jul 1, 1991·Journal of Computer Assisted Tomography·G BrixW J Lorenz
Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P S Tofts, A G Kermode
Oct 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H B LarssonO B Paulson
Jan 1, 1987·Alzheimer Disease and Associated Disorders·A B ScheibelU Tomiyasu
Jun 1, 1984·Journal of Computer Assisted Tomography·F W WehrliR J Herfkens
Jun 1, 1993·Neurological Research·J C de la Torre, T Mussivand
May 1, 1994·Journal of Computer Assisted Tomography·F GückelM Georgi
Sep 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S BlümlW J Lorenz
Jan 1, 1993·Magnetic Resonance Imaging·P S ToftsJ M Pope
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R G ShulmanG McCarthy
May 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D M ShamesR C Brasch
Jul 1, 1997·Neurobiology of Aging·H Braak, E Braak
Jul 1, 1997·Neurobiology of Aging·W SilvermanJ Wegiel

❮ Previous
Next ❯

Citations

Feb 13, 2009·Psychiatry Research·John M StarrJoanna Wardlaw
Jul 31, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang Lu, Yulin Ge
Jan 3, 2013·Contrast Media & Molecular Imaging·Yoshiteru SeoMasataka Murakami
Oct 30, 2010·Magnetic Resonance Imaging·Paul A ArmitageJoanna M Wardlaw
May 12, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Charles GasparovicLeslie A Morrison
Oct 19, 2005·Investigative Radiology·Martin RohrerHanns-Joachim Weinmann
Oct 29, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang LuJoseph A Helpern

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Stephen PickupHarold L Kundel
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
K M DonahueM L Gray
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
P S Tofts, A G Kermode
© 2022 Meta ULC. All rights reserved